目的 系统评价润燥止痒胶囊联用组胺H1受体拮抗剂治疗老年皮肤瘙痒症的临床疗效和安全性，为临床推广提供理论依据。方法 计算机检索PubMed、Medline、中国生物医学文献数据库（CBM）、中国学术期刊全文数据库（CNKI）、维普中文科技期刊数据库（VIP）、万方数据库，收集润燥止痒胶囊联用组胺H1受体拮抗剂与单用组胺H1受体拮抗剂治疗老年皮肤瘙痒症临床随机对照研究，采用RevMan 5.2软件进行Meta分析。结果 共纳入18项研究，2 003例患者。Meta分析结果显示，与单用组胺H1受体拮抗剂，润燥止痒胶囊联用组胺H1受体拮抗剂能显著提高的临床有效率[RR=1.45，95% CI （1.36，1.54），P<0.01]，降低瘙痒程度评分[MD=-2.83，95% CI （-3.51，-2.15），P<0.01]、瘙痒持续时间[MD=-2.14，95% CI （-2.49，-1.79），P<0.01]、瘙痒发作频率[MD=-2.39，95% CI （-2.81，-1.96），P<0.01]、瘙痒面积[MD=-1.60，95% CI （-1.94，-1.26），P<0.01]和继发皮损评分[MD=-1.87，95% CI （-2.48，-1.27），P<0.01]和ADR发生率[RR=0.67，95% CI （0.52，0.88），P<0.01]。结论 润燥止痒胶囊联用组胺H1受体拮抗剂治疗老年皮肤瘙痒症的临床疗效优于单用组胺H1受体拮抗剂。

Objective To systematically review the efficacy and safety of Runzao Zhiyang Capsule combined with Histamine H1 receptor antagonists in treatment of senile skin pruritus, to provide theoretical basis for clinical popularization.Methods Databases including PubMed, Medline, CNKI, VIP and WanFang Data were searched to collect randomized controlled trials (RCTs) about Runzao Zhiyang Capsule combined with Histamine H1 receptor antagonists vs Histamine H1 receptor antagonists alone in treatment of senile skin pruritus. Then Meta-analysis was conducted by RevMan 5.2 software.Results Total of 18 RCTs, 2003 patients were included. Meta-analysis showed that, compared to histamine H1 receptor antagonists alone, Runzao Zhiyang Capsule combined with histamine H1 receptor antagonists could improved clinical effective rate[RR=1.45, 95% CI(1.36, 1.54), P< 0.01], lower the degree of itching score[MD=-2.83, 95% CI(-3.51, -2.15), P< 0.01], duration of itching[MD=-2.14, 95% CI(-2.49, -1.79), P< 0.01], itching frequency[MD=-2.39, 95% CI(-2.81, -1.96), P< 0.01], itching area[MD=-1.60, 95% CI(-1.94, -1.26), P< 0.01], secondary skin lesions[MD=-1.87, 95% CI(-2.48, -1.27), P< 0.01] and rate of ADR[RR=0.67, 95% CI(0.52, 0.88), P< 0.01].Conclusion Current evidence shows that the clinical curative effect of Runzao Zhiyang Capsule combined with histamine H1 receptor antagonists in treatment of senile skin pruritus much better than histamine H1 receptor antagonists alone.

黄石市医药卫生科研指导项目[黄卫生计生通（2016）-270-14]