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目的 评价疏风解毒胶囊口服加外用联合治疗激素依赖性皮炎的临床效果。方法 2013年6月-2015年5月重庆市职业病防治院皮肤科诊治的激素依赖性皮炎患者,按就诊时间分入疏风解毒组与他克莫司组,所有患者停用激素类药物及可疑含激素化妆品,并进行心理安抚治疗,告知治疗过程中可能出现的反应症状。疏风解毒组予疏风解毒胶囊口服,4粒/次,3次/d,同时予3粒疏风解毒胶囊去除胶囊200 mL温水溶解后面部湿敷,>4次/d,疗程4周;他克莫司组0.1%他克莫司软膏,早晚各1次,疗程4周。疗程结束后,未达到有效治疗的患者予两组方案交替治疗,继续治疗4周。观察两组临床治疗效果,对所有达到有效治疗的患者随访至论文撰写阶段了解治疗效果。结果 疏风解毒组共诊治39例,第1阶段有效率87.2%,他克莫司组36例,第1阶段有效率达68.6%,疏风解毒组有效率高于他克莫司组,差异有统计学意义(P<0.05);第一阶段未能达到有效治疗的患者,在交替治疗方案后均达到有效治疗。随访阶段,疏风解毒组平均随访时间为(7.9±2.7)月,有6例患者复发,平均复发时间为(6.8±1.4)月,复发时症候积分为(10.3±2.9)分;他克莫司组随访时间为(7.6±1.8)月,有13例复发,平均复发时间为(5.1±1.8)月,复发时症候积分为(13.2±2.2)分。疏风解毒组复发率、复发症候积分均小于他克莫司组,差异有统计学意义(P<0.05);复发时间大于他克莫司组,差异有统计学意义(P<0.05);两组随访时间差异比较无统计学意义。他克莫司组开始治疗时有3例患者出现轻微皮肤灼热、刺痛,不影响治疗,对症处理后不适症状消失,疏风解毒胶囊治疗组未见不良反应。结论 疏风解毒胶囊内外联合治疗激素依赖性皮炎疗效确切,能减少激素依赖性皮炎复发,即可作为首选治疗,也可作为其他治疗失败后的补充治疗。
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[Abstract]
Objective To evaluate the clinical effect of Shufeng Jiedu capsules for oral and external use in the treatment of hormone dependent dermatitis.Methods From 2013-6 to 2015-5, all patients with hormone dependent dermatitis were divided into Shufeng Jiedu group and Tacrolimus group. All patients discontinued hormone drugs, cosmetics containing hormone, and gained psychotherapy. Shufeng Jiedu group with Shufeng Jiedu capsules. Tacrolimus group with 0.1% tacrolimus ointment. The course of treatment for 4 weeks. After the treatment for 4 weeks. If the patients without effective therapy, we alternated the treatment in the two groups for 4 weeks. The clinical curative effect would be evaluated.Results 39 patients in the Shufeng Jiedu group, the effective rate was 87.2% in the first stage; 36 patients in the tacrolimus group, the effective rate was 68.6% in the first stage (P< 0.05). All patients without effective treatment would gain better after the altnative use of Shufeng Jiedu Capsules and tacrolimus ointment. There were no difference in follow-up period between two groups. There were 6 patients in recurrence in the Shufeng Jiedu group, the recurrence time was (6.8 ±1.4) months, recurrence syndrome integral was (10.3 ±2.9). There were 13 patients in recurrence in Tacrolimus group,the recurrence time was (7.6 ±1.8) months, recurrence syndrome integral was (13.2 ±2.2). The recurrence rate and recurrence syndrome integral of Shufeng Jiedu group were less than these of tacrolimus group (P< 0.05), the recurrence time of Shufeng Jiedu group was better than that of tacrolimus group (P< 0.05). Three patients with mild skin burning and tingle when starting treatment in the Tacrolimus group, but no effect on treatment. Shufeng Jiedu group without adverse reactions.Conclusions There would have a good effect on hormone dependence dermatitis by Shufeng Jiedu capsules for oral and external use, and could reduce the recurrence.
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