目的 探讨甲泼尼龙联合阿奇霉素治疗小儿肺炎支原体大叶性肺炎的临床效果。方法 将西安市中心医院自2014年1月-2016年12月收治的肺炎支原体大叶性肺炎患儿122例作为研究对象，随机分为研究组和对照组各61例，患儿入院后给予相应的对症治疗，其中对照组给予阿奇霉素进行治疗，研究组患儿在对照组治疗的基础上联合甲泼尼龙进行治疗，观察两组患儿的临床疗效。结果 治疗前两组患儿C反应蛋白（CRP）指标比较差异不大，治疗后均明显降低，其中研究组患儿降低程度显著优于对照组，研究组患儿体温恢复时间和住院时间均显著少于对照组，差异具有统计学意义（P < 0.05）。研究组患儿临床总有效率为98.59%，显著高于对照组84.85%，组间比较差异具有统计学意义（P < 0.05）。两组均未发生严重不良反应。结论 甲泼尼龙联合阿奇霉素治疗小儿肺炎支原体大叶性肺炎能够较好的缓解症状，降低CRP水平，效果显著，安全有效，可推广使用。

Objective To investigate the clinical effect of azithromycin combined with methylprednisolone in the treatment of mycoplasma pneumoniae. Methods A total of 122 children with mycoplasma pneumoniae pneumonia were enrolled in our hospital from January 2014 to December 2016. They were randomly divided into study group and control group (61 cases). The corresponding symptomatic treatment, which control the oral administration of azithromycin treatment, the study group of children in the control group based on the treatment of methylprednisolone treatment, to observe the clinical efficacy of the two groups of children. Results There was no significant difference in CRP between the two groups before treatment, and the levels of CRP in the study group were significantly lower than those in the control group. The recovery time and hospitalization time of the study group were significantly lower than those of the control group, The total effective rate was 98.59% in the study group, which was significantly higher than that in the control group (84.85%). There was significant difference between the two groups (P < 0.05). There had no serve adverse reactions in two groups. Conclusion Azithromycin combined with methylprednisolone can reduce the level of CRP in children with mycoplasma pneumoniae, which can alleviate the symptoms and reduce the level of CRP. The effect is remarkable and can be popularized.