[关键词]
[摘要]
多药耐药(MDR)是指肿瘤细胞接触一种抗肿瘤药物后,也对其他多种结构不同、功能不同的抗肿瘤药物产生耐药性,其中外排型转运体所介导的MDR是其中至关重要的一部分。外排型转运体是指位于肿瘤细胞生物膜上的具有将抗肿瘤药物从细胞内外排到细胞外的转运体。已知的具有外排作用的转运体有P糖蛋白(P-gp)、多药耐药相关蛋白(MRP)、乳腺癌耐药蛋白(BCRP)和肺耐药蛋白(LRP)。综述这几种外排型转运体的一般性质并着重于阐述逆转这些转运体介导的多药耐药的药物及方法。
[Key word]
[Abstract]
Multidrug resistance (MDR) refers to the resistance that the cancer cells will display to multiple structurally dissimilar and functionally diverse drugs after exposing to an anticancer drug and MDR mediated by efflux transporters is one crucial part of MDR. Multidrug resistance (MDR) is defined as the resistance to Efflux transporters, located in the biological membranes, can extrudea variety of structurally diverse drugs from the cell. There are several sorts of known efflux transporters:P-glycoprotein (P-gp), the multidrug resistance proteins (MRPs) 1-5, the breast cancer resistance protein (BCRP) and lung resistant protein. This review concentrates the general propertieson those efflux transporters and the revier will be more focus on the drugs and methods to reversing MDR.
[中图分类号]
[基金项目]
国家自然科学基金项目(81473280)