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[摘要]
齐墩果酸具有广泛的药理作用,包括抗炎、抗肿瘤、抗糖尿病、抗动脉粥样硬化,保肝、抗骨质疏松等。但是齐墩果酸口服的生物利用度低,通过被动扩散被肠道吸收,齐墩果酸的分散体制剂能提高溶出度和生物利用度,且能浓集于肝脏,有利于治疗肝部疾病。通过综述齐墩果酸药动学参数、体内过程、齐墩果酸分散体及其前药的药动学特征,总结齐墩果酸的药动学研究进展,为合理用药提供参考。
[Key word]
[Abstract]
Oleanolic acid has a widespread pharmacologic effect, including anti-inflammation, antitumor, antidiabetes, anti-atherosclerosis, hepatoprotection, anti-osteoporosis, etc. Bioavailability of oleanolic acid by oral administration is low, and is absorbed by intestine through passive transport. Oleanolic acid dispersion preparation can increase its solubility and bioavailability, and concentrate on liver to help treat for hepatic disease. The pharmacokinetic parameters, process in body of oleanolic acid, and the pharmacokinetic feature of oleanolic acid dispersion and its prodrug are reviewed, and its research advance on pharmacokinetics is summarized, which provides a reference for rational utilization of oleanolic acid.
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