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[摘要]
目的 探讨槐杞黄颗粒辅助治疗儿童支气管哮喘的临床疗效及对患儿免疫功能的影响。方法 将100例支气管哮喘患儿随机分为对照组与治疗组各50例,均接受常规西医治疗,治疗组同时辅以槐杞黄颗粒治疗,2次/d,<3岁5.0 g/次, ≥ 3岁10 g/次。两组均治疗3个月。比较两组治疗前后白细胞介素-4(IL-4)、IL-5和γ干扰素(IFN-γ)水平,日间和夜间症状积分,临床疗效及随访3个月的复发率。结果 两组治疗后血清IL-4、IL-5水平均明显降低,IFN-γ水平均明显升高,同组治疗前后比较差异有统计学意义(P<0.05);治疗组血清IL-4、IL-5水平明显低于对照组,IFN-γ水平明显高于对照组,组间差异有统计学意义(P<0.05)。两组治疗后日间和夜间症状积分均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗组明显低于对照组,组间比较差异有统计学意义(P<0.05)。治疗组总有效率(96.0%)明显优于对照组(82.0%),差异有统计学意义(P<0.05)。治疗组复发3例(6.0%),对照组复发12例(24.0%),治疗组复发率明显低于对照组,差异有统计学意义(P<0.05)。结论 槐杞黄颗粒辅助治疗能有效改善支气管哮喘患儿的免疫功能,增强疗效,减少复发。
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[Abstract]
Objective To investigate Huaiqihuang particles in treatment of children with bron chialasthma and effect on immune function. Methods 100 cases of children with bronchial asthma were randomly divided into control group and treatment group, 50cases in each group, all were given routine western medicine treatment, and the treatment group combined with Huaiqihuang particles. The levels of interleukin-4 (IL-4), IL-5 and interferon gamma (IFN-γ), diurnal and nocturnal symptom scores before and after treatment and clinical efficacy and recurrence rate in followed up for 3 months in two groups were compared. Results After treatment, serum IL-4, IL-5 levels of the two groups were significantly decreased, IFN-γ levels were significantly increased in the same group before and after treatment, the difference was statistically significant (P < 0.05)., serum IL-4 and IL-5 levels of treatment group were significantly lower than the control group, IFN-γ levels were significantly higher than the control group, there was statistically significant difference between groups (P < 0.05). After treatment, daytime and nighttime symptom scores of two groups were significantly reduced than before treatment (P < 0.05). And the treatment group was significantly lower than the control group (P < 0.05). The total effective rate of the treatment group (96%) was significantly better than that of the control group (82%) (P < 0.05). The treatment group recurred in 3 cases (6%), and the control group relapsed in 12 cases (24%). The recurrence rate of the treatment group was lower than that of the control group (P < 0.05). Conclusion Huaiqihuang particles can effectively improve the immune function of patients with bron chialasthma, enhance efficacy and reduce recurrence.
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