目的 对比分析阿托伐他汀、辛伐他汀、瑞舒伐他汀对高脂血症的治疗效果。方法 选择2014年1月-2016年1月在商南县医院进行诊治的高脂血症患者120例，随机分为阿托伐他汀组、辛伐他汀组以及瑞舒伐他汀组，分别采用阿托伐他汀、辛伐他汀、瑞舒伐他汀治疗，3组均治疗8周。比较3组治疗前、治疗第4周和治疗第8周的血脂水平，以及不良反应发生情况。结果 3组治疗第4周和治疗第8周的血脂水平均明显改善，同组治疗前后比较差异有统计学意义（P<0.05）；且瑞舒伐他汀组明显优于阿托伐他汀组和辛伐他汀组，组间比较差异有统计学意义（P<0.05）。3组的不良反应发生率相比无明显差异。结论 阿托伐他汀、辛伐他汀和瑞舒伐他汀均可以有效改善高脂血症患者的血脂水平，且瑞舒伐他汀的治疗效果最佳。

Objective To compare the efficacy of atorvastatin, simvastatin and rosuvastatin in the treatment of hypercholesterolemia. Methods Selected 120 cases of patients with hypercholesterolemia who were treated in our hospital from January 2014 to December 2016, divided into atorvastatin group, simvastatin group and rosuvastatin group. The blood lipid levels and the incidence of adverse reactions were compared between the three groups before treatment, after treatment for fourth weeks and after treatment for eighth weeks. Results The serum lipid level were significantly improved in three groups after treatment (P<0.05), and rosuvastatin group was significantly better than atorvastatin group and simvastatin group (P<0.05); the incidence of adverse reactions of the three groups showed no significant difference. Conclusion Atorvastatin, simvastatin and rosuvastatin can effectively improve the blood lipid levels in patients with hypercholesterolemia, and the effect of rosuvastatin is the best.