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[摘要]
目的 比较盐酸米诺环素联合甲硝唑或替硝唑治疗慢性牙周炎的疗效及安全性。方法 选取2014年2月-2016年2月于西安市第九医院进行治疗的慢性牙周炎患者260例作为研究对象,采用随机数字表法将其分为观察组与对照组各130例。对照组患者使用盐酸米诺环素联合甲硝唑治疗,观察组患者使用盐酸米诺环素联合替硝唑治疗,疗程均为4周。对比两组患者临床疗效、牙周各项指标以及不良反应。结果 观察组治疗总有效率为94.62%,明显高于对照组的83.85%,差异有统计学意义(P<0.05)。治疗后,两组患者牙周各指标均较治疗前明显改善,其中观察组各指标均优于对照组,差异有统计学意义(P<0.05)。治疗期间,观察组不良反应发生率为8.46%,对照组为14.62%,两组差异不显著。观察组复发率为1.54%,对照组为6.92%,两组差异不显著。结论 盐酸米诺环素联合替硝唑治疗慢性牙周炎疗效高于盐酸米诺环素联合甲硝唑治疗,安全性高,值得临床推广。
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[Abstract]
Objective To compare the clinical effect and safety of minocycline hydrochloride combined with metronidazole or tinidazole in treatment of chronic periodontitis. Methods Patients with chronic periodonitis (260 cases) accepted in Ninth Hospital of Xi'an from February 2014 to February 2016 were randomly divided into observation group and control group with 130 cases in each group. Patients in control group were given minocycline hydrochloride combined with metronidazole, and patients in observation group were given minocycline hydrochloride combined with tinidazole. Then the clinical effect, periodontal indexes and adverse reactions of two groups were compared. Results The total effective rate of observation group was 94.62%, which was obviously higher than that of control group (83.85%, P<0.05). The periodontal indexes of observation group were higher than control group (P<0.05). The adverse reaction rate of observation group was 8.46%, that of control group was 14.62%, which had no differences. The recurrence rate of observation group was 1.54%, that of control group was 6.92%, which had no differences. Conclusion Using minocycline hydrochloride combined with tinidazole has better effect in treatment of chronic periodontitis, which is safety and worthy of clinical application.
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