[关键词]
[摘要]
肝脏是机体重要的代谢和解毒器官。肝细胞膜上存在多种功能性膜蛋白即肝脏药物转运体,它的功能是介导许多内源性及外源性物质如药物摄取进入肝脏,在肝脏内经过一定的代谢转化,最终将其从肝脏排入胆汁。研究发现,转运体和代谢酶在化学性肝损伤的发展过程中发挥重要的作用,其涉及的多种调控机制成为研究热点。就肝脏转运体和代谢酶的分类、转运体和代谢酶在化学性肝损伤中的变化及其调控机制作一综述。
[Key word]
[Abstract]
Liver is an important metabolic and detoxification organ in the body. Hepatic transporters are a series of functional membrane proteins that are extensively expressed in the liver. They are responsible for the uptake of endogenous and exogenous substances such as medicines into hepatocytes and excretion of their metabolic products into bile. Recent studies have provided that transporters and metabolic enzymes play important roles in the chemical substances-induced liver injury, and its various regulatory mechanisms have become hot topics of research. In this paper, we summarize the classification of hepatic transporters and metabolic enzymes and the changes of transporters and metabolic enzymes in the chemical substances-induced liver injury and its regulatory mechanism.
[中图分类号]
[基金项目]
国家自然科学基金项目(81473280)