[关键词]
[摘要]
固体分散体作为一种制剂的中间体,在改善难溶性药物的溶出与提高其生物利用度方面发挥了重要的作用。固体分散技术是提高难溶性药物的溶出与溶解度最具应用潜力的新技术之一,其发展将推动制剂领域日臻完善。重点从固体分散体的载体材料、各种新型制备技术及其比较、固体分散剂型的应用与稳定性问题4个方面展开介绍,阐述了影响固体分散体稳定性的因素,并提出了防止其老化的有效措施,最后对固体分散技术的发展提出了中肯的建议。
[Key word]
[Abstract]
Solid dispersions (SD) as a preparation of intermediates have played an important role in improving the dissolution of insoluble drugs and its bioavailability. SD technique is one of the most promising techniques to improve the dissolution and solubility of insoluble drugs, and the development of SD technique will promote the gradual perfection in preparative field. This review focuses on the carrier materials of SD, various new preparation techniques and their comparisons, application of solid dispersion formulations, and stability problems of SD. The factors influencing the stability of SD are described, and the effective measures to prevent the aging of SD are put forward. Finally, the review puts forward the practical suggestions of the solid dispersion technique.
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[基金项目]