[关键词]
[摘要]
侵袭与转移为恶性肿瘤的重要生物学特征,也是临床肿瘤治疗失败和高死亡率的重要原因,寻找安全有效的抗肿瘤转移药物已成为转化医学的一项迫切任务。中药单体成分姜黄素、贝母乙素、β-榄香烯等以其疗效确切、毒副作用小等优势,成为近年来抗肿瘤转移药物研究和开发的热点。综述了近年来中药单体成分抗肿瘤侵袭转移的研究进展。
[Key word]
[Abstract]
As the essential characteristics of malignant cancer, invasion and metastasis are the main reason for failure treatment and high death rate of cancer patients. It is necessary to find out safe and effective anti-invasion and anti-metastasis drugs for the improvement of clinical efficacy. With the definite therapeutic effect and mild side-effects, Chinese materia medica(CMM) including curcumin, peiminine, β-elemi and so on, have become hotspots in anti-invasion and anti-metastasis drugs research. The mechanisms for the effective ingredients of CMM anti-tumor invasion and metastasis were reviewed in this paper.
[中图分类号]
[基金项目]
中国博士后科学基金面上项目(2016M591398);天津医科大学基本科研业务费资助项目(2016YD07);天津医科大学科学基金青年项目(2015KYZQ13)