疫苗的免疫接种是预防传染病的最有效方法之一。近年以来随着生物技术迅猛发展，B群脑膜炎球菌疫苗的研究也取得了突破性发展，应用反向疫苗学技术开发的新型B群脑膜炎球菌疫苗已陆续被欧洲医药管理局和美国食品和药品管理局批准上市。尽管目前国内尚未批准相关产品上市，但一些企业和研究院所已在加紧研发。为了进一步了解B群脑膜炎球菌疫苗，推动国内B群脑膜炎球菌疫苗的研发，综述不同类型B群脑膜炎球菌疫苗的研究现状及其面临的挑战。

It is generally accepted that vaccinations are one of the most effective tool for control of infectious diseases. In recent years, the research on meningococcal group B vaccines has made progress extensively. A new meningococcal group B vaccine, developed by the reverse vaccinology technology, has been approved by the European Medicines Agency and the Food and Drug Administration. Although no related products has been approve till now in China, some meningococcal group B vaccines are also developing in domestic companies and research institutes. Therefore, to further understand these vaccines and facilitate the development of meningococcal group B vaccines, this paper reviews advance and challenge in research on meningococcal group B vaccines.

国家重大新药创制项目（2013ZX09304101）