目的 探讨鼠神经生长因子（mNGF）治疗急性脑梗死的疗效及对脑源性神经营养因子（BDNF）、胰岛素样生长因子-1（IGF-1）和白细胞介素-33（IL-33）水平的影响。方法 选取2015年10月—2017年2月廊坊市第四人民医院收治的急性脑梗死患者106例为研究对象。按照数字列表法，将患者随机分为对照组和治疗组，每组53例。对照组采取常规急性脑梗死治疗方案，治疗组在对照组治疗基础上加用mNGF 18 μg，肌肉注射，1支/次，1次/d，共治疗14 d。治疗前及治疗14 d后应用美国国立卫生研究院脑卒中量表（NIHSS）对两组患者进行神经功能缺损程度评分，采用酶联免疫吸附法测定血清BDNF、IGF-1和IL-33水平。结果 与治疗前比较，两组患者治疗14 d后NIHSS评分均明显下降，差异有统计学意义（P<0.05）；治疗组NIHSS评分下降值明显大于对照组，差异有统计学意义（P<0.05）。治疗组治疗后总有效率（93.4%）明显优于对照组（46.6%），差异有统计学意义（P<0.05）。与治疗前比较，两组治疗14 d后血清BDNF、IGF-1水平升高，IL-33水平下降，同组治疗前后比较差异有统计学意义（P<0.05），但治疗组变化程度明显大于对照组，差异有统计学意义（P<0.05）。结论 mNGF可显著减轻脑梗死患者神经功能缺损程度，并可有效上调BDNF、IGF-1和下调IL-33表达水平。

Objective To observe the curative effect of mouse nerve growth factor and its influence on levels of BDNF, IGF-1, and IL-33 in patients with acute cerebral infarction.Methods Totally 106 cases of patients with acute cerebral infarction were chosen as the research objects between October 2015 and February 2017 in Fourth People’s Hospital of Langfang City. According to digital list method, the patients were randomly divided into treatment group and control group, 53 cases in each group. The patients in two groups were treated with conventional medicine of acute cerebral infarction, and the patients in treatment group were added to mNGF on the basis of conventional drugs, im injection, 18 μg each time, once daily. The patients in control group were not added to NGF treatment, and the patients in two groups were treated for 14 d. Before and after treatment, the degrees of neural function defect in two groups were scored according to NIH Stroke Scale (NIHSS), serum levels of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and interleukin-33 (IL-33) were determinated using enzyme-linked immunosorbent method.Results Compared with those before treatment, NIHSS scores decreased (P<0.05) after 14 d of treatment in two groups, but the reduced value in treatment group was obviously higher than that in control group (P<0.05). After treatment, the total effective rate (93.4%) of treatment group was better than that of control group (46.6%), and the difference was statistically significant (P<0.05). Compared with before treatment, serum levels of BDNF and IGF-1 rised (P<0.05), IL-33 decreased (P<0.05) after 14 d of treatment in two groups, but the changes in treatment group were significantly greater than those in control group (P<0.05).Conclusion mNGF can effectively reduce the severity of nervous functional defects, and effectively increase expression levels of BDNF and IGF 1 and decreasedexpression level of IL-33.

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