[关键词]
[摘要]
红景天苷能对抗缺氧、H2O2、高糖、高同型半胱氨酸、烟雾、失重对血管内皮细胞的损伤;对抗缺氧、高糖、去甲肾上腺素、血小板源生长因子、血管紧张素Ⅱ诱导血管平滑肌细胞或血管外膜成纤维细胞增殖,从而产生血管保护作用并改善血管功能。红景天苷对阻力血管具有收缩和舒张的双重调节作用;其血管舒张作用是内皮和非内皮依赖性的,能对抗KCl、CaCl2、去甲肾上腺素、苯肾上腺素、高同型半胱氨酸、高血糖、高原缺氧、H2O2、氯气等对血管的挛缩和损伤作用。红景天苷能解除蛛网膜下腔出血致脑血管痉挛,抑制大鼠因缺氧或野百合碱引起的肺动脉高压和肺血管重建,抑制多种实验性动脉粥样硬化形成并提高动脉粥样斑块的稳定性。
[Key word]
[Abstract]
Salidroside antagonizes hypoxia, H2O2, hyper-glucose, homocysteine, smoking, orweightlessness-induced endothelial cell injury, and antagonizes the proliferation of vascular smooth muscle cells and vascular adventitial fibroblasts induced by hypoxia, hyper-glucose, noradrenaline, platelet-derived growth factor, or angiotensinⅡ,thus produces vascular protection and improves vascular function. Salidroside plays a dual role of vasoconstriction and vasodilation in regulating resistant blood vessel. The vasodilatory effect of salidrosideis endothelium-dependent and endothelium-independent. Salidroside antagonizes vascular contraction and injury induced by KCl, CaCl2, noradrenaline, phenylephrine, homocysteine, hyper-glucose, plateau hypoxia, H2O2, and chlorine. Salidroside relieves cerebral vasospasm induced by subarachnoid hemorrhage, and pulmonary hypertension and pulmonary arterial remodeling induced by hypoxia or monocrotaline in rat, attenuates several experimental atherosclerosis, and enhances plaque stability.
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