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[摘要]
目的 研究孟鲁司特钠联合沙美特罗氟替卡松治疗支气管哮喘患者的效果。方法 采用前瞻性研究方法,选择2014年4月-2016年3月在四川省第四人民医院诊治的98例支气管哮喘患者作为研究对象,根据随机抽签原则把上述患者分为观察组与对照组各49例,对照组给予沙美特罗氟替卡松治疗,观察组给予孟鲁司特钠联合沙美特罗氟替卡松治疗,均治疗观察15d,比较两组临床疗效、肺功能及生活质量评分情况。结果 治疗后观察组总有效率为95.9%,明显高于对照组的81.6%,差异有统计学意义(P<0.05)。治疗后两组FEV1、FVC值和ACT评分都明显高于治疗前,同组治疗前后比较差异有统计学意义(P<0.05),且治疗后观察组以上指标明显高于对照组,组间比较差异有统计学意义(P<0.05)。治疗期间,两组不良反应率无统计学差异。结论 孟鲁司特钠联合沙美特罗氟替卡松治疗支气管哮喘患者能促进肺功能的改善,从而提高治疗疗效与生活质量。
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[Abstract]
Objective To compare the effects of salmeterol and fluticasone propionate combined montelukastin the treatment of patients with bronchial asthma. Methods Ninety-eight bronchial asthma patients from April 2014 to March 2016in the Fourth People’s Hospital Sichuan Province were selected anddivided into observation group and control group with 49 patients in each group according to the above principles by prospective study. The control group was given salmeterol treatment, and the observation group was added given montelukast treatment based on the control group.The treatment days were 15d recorded the prognosis of the two groups. Results The total effective rates of the observation group and the control group were 95.9% and 81.6% respectively, the total effective rate of the observation group was significantly higher than that of the control group (P<0.05). The FEV1 and FVC values after treatment in the observation group and control group were significantly higher than before treatment (P<0.05), while the FEV1 and FVC values in the observation group after treatment were significantly higher than those in the control group (P<0.05). The scores of ACT scale after treatment of two groups were obviously higher than before treatment, and the score of observation group was statistically higher than control group after treatment (P<0.05).During treatment, there was no statistical significance on adverse reaction between two groups.Conclusion Salmeterol and fluticasone propionate combined montelukast in the treatment of patients with bronchial asthma can promote the improvement of lung function, so as to improve the quality of life and clinical treatment.
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