[关键词]
[摘要]
目的 分析单唾液酸四己糖神经节苷脂联合依达拉奉治疗急性脑梗死的疗效及对血清相关指标的影响。方法 以2010年10月-2016年5月榆林市第一医院急诊救治的126例急性脑梗死患者为研究对象,根据就诊顺序分为观察组和对照组,每组63例。对照组患者在常规治疗基础上给予依达拉奉注射液,观察组在对照组的基础上加用单唾液酸四己糖神经节苷脂钠注射液,两组均连续治疗2周。比较两组的临床疗效,美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数评分,血清神经元特异性烯醇化酶(NSE)、S100β蛋白、氧化应激相关指标[超氧化物歧化酶(SOD)、晚期氧化蛋白产物(AOPP)和丙二醛(MDA)]水平在治疗前后的变化情况。结果 观察组的总有效率(90.48%)显著高于对照组(76.19%),两组比较差异有统计学意义(P<0.05)。治疗2周后,两组的NIHSS和Barthel指数评分均较治疗前显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组NIHSS和Barthel指数评分显著低于对照组,差异有统计学意义(P<0.05)。两组的NSE、S100β蛋白、AOPP、MDA水平较治疗前显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组的以上指标显著低于对照组,差异有统计学意义(P<0.05);SOD水平较治疗前显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且观察组的显著高于对照组,差异有统计学意义(P<0.05)。结论 单唾液酸四己糖神经节苷脂可协同提高依达拉奉治疗急性脑梗死的临床疗效,促进患者神经功能及生活能力恢复,且发挥协同作用的机制可能与协同改变血清NSE、S100β蛋白、SOD、AOPP、MDA水平有关。
[Key word]
[Abstract]
Objective To investigate the influence of Trisialoganglioside-GT1b combined with Edaravone Injection on clinical effect and serumrelatedindicators in patients with acute cerebral infarction.Methods A total of126 cases of patients with acute cerebral infarction in our hospital from October 2010 to May 2016 were selected and divided into observation group and control group,63 cases in each group.Patients in the control group were treated with regular treatment and Edaravone Injection, and patients in the observation group were treated with regular treatment, Edaravone Injection and Trisialoganglioside-GT1b.The clinical effect, NIHSS scores, Barthel index scores, serum level of neuron specific enolase (NSE), S100β protein, superoxyde dismutase(SOD), advanced oxidation protein products(AOPP) and malondiadehyde(MDA) were compared.Results The total effective rate of the observation group (90.48%) was significantly higher than that of the control group (76.19%), the difference between the two groups was statistically significant (P< 0.05).After two weeks of treatment, two groups of NIHSS and Barthel index scores were significantly lower than before treatment, the difference was statistically significant (P< 0.05); and the NIHSS and Barthel index scores of observation group were significantly lower than that of control group, the difference was statistically significant (P< 0.05).NIHSS scores, Barthel index scores of the observation group were significantly better than that of the control group(P<0.05);The serum level of NSE, S100, AOPP, MDA of two groups after treatment were significantly lower than that before treatment, the difference was statistically significant (P< 0.05); and the above indexes of the observation group was significantly lower than the control group, the difference was statistically significant (P< 0.05); SOD levels of two groups were significantly increased than before treatment, the difference was statistically significant (P< 0.05); and the SOD levels of observation group was significantly higher than that of control group, the difference was statistically significant (P< 0.05).Conclusion Trisialoganglioside-GT1b can synergy improve the clinical effect of Edaravone Injection in patients with acute cerebral infarction, and be good to recovery the neurologicfunctionandabilityofdaily living,and these may be related to the change of the serum level of NSE, S100βprotein, SOD, AOPP and MDA.
[中图分类号]
[基金项目]