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[摘要]
目的 探究热毒宁注射液联合脾氨肽口服液治疗小儿手足口病的疗效及对机体心肌酶、免疫水平的调节作用。方法 选择2014年9月—2016年9月期间开封市儿童医院收治的184例小儿手足口病患儿,按照入院就诊顺序将184例患儿分为观察组和对照组,每组92例,另选择20名年龄、性别匹配的健康体检儿童为健康组。对照组给予常规治疗,观察组在对照组基础上给予热毒宁注射液联合脾氨肽口服液治疗。比较两组患者的临床有效率、心肌酶、炎症因子、免疫水平。结果 观察组患者临床总有效率为93.48%(86/92),对照组患者的临床总有效率为80.43%(74/92),观察组患者的临床疗效明显优于对照组(P<0.05);治疗后,观察组患儿血清hs-cTnT、CK-MB、CK、TNF-α、IL-6、CRP、CD3+、CD4+、CD8+、IgA、IgM、IgG与健康组比较,差异无统计学意义;对照组上述指标与治疗前相比,显著改善,然而与健康组比较,仍具有显著性差异(P<0.05)。结论 热毒宁联合脾氨肽可有效控制手足口病患儿全身炎症反应,修复心肌损伤,临床疗效确切,值得临床推广。
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[Abstract]
Objective To investigate the effect of Reduning Injection (RI) combined with spleen aminopeptide oral solution on children with hand-foot-and-mouth disease and its regulative effect on myocardial enzyme and inflammatory level. Methods Totally 184 cases treated in Children's Hospital of Kaifeng City from September, 2014 to September, 2016 were randomly divided into observation group and control group with each group of 92 cases. Control group was given conventional therapy, on the basis of which, observation group was given RI combined with spleen aminopeptide oral solution. Clinical effect and levels of inflammatory cytokine and myocardial enzyme were compared between the two groups. Results The total effective rate in observation group was 93.48%, which was significantly higher than that in control group (80.43%) (P< 0.05). After therapy, the levels of hs-cTnT, CK-MB, CK, TNF-α, IL-6, CRP, CD3+, CD4+, CD8+, IgA, IgM, and IgG in observation group showed no statistical difference compared with healthy group. Index mentioned above of control group were significantly improved, however there were still statistical difference compared with healthy group (P< 0.05). Conclusion RI combined with spleen aminopeptide oral solution could effectively decrease the levels of inflammatory cytokine as well as myocardial enzyme, which deserves clinical expansion.
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