[关键词]
[摘要]
柚皮苷主要存在于芸香科柑橘属植物柚、葡萄柚、酸橙及其变种的果皮及果实中,属于双氢黄酮类化合物。研究表明柚皮苷具有抗1型及2型糖尿病的药理作用,作用机制为通过抑制糖尿病相关的氧化应激损伤、炎症、糖代谢酶异常等方面,同时在一定程度上延缓糖尿病并发症(包括糖尿病心肌病、糖尿病肾病、糖尿病视网膜病变及糖尿病神经病变)的发生与发展。探讨柚皮苷对糖尿病及其并发症作用机制的研究进展,旨在为抗糖尿病新药研发提供依据。
[Key word]
[Abstract]
Naringin is mainly present in Rutaceae Citrus Pomelo, grapefruit, lime, and its variants of the peel and fruit, which belongs to dihydrogen flavonoids. Studies have shown that naringin has anti-type 1 and type 2 diabetes pharmacological effects, the mechanism of action by inhibiting diabetes-related oxidative stress injury, inflammation, abnormal metabolism of glucose, and other aspects, while a certain degree of delay in diabetes complications (including diabetic cardiomyopathy, diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy). The mechanism of naringin on the mechanism of diabetes mellitus and its complications was studied in order to provide the basis for the development of antidiabetic drug.
[中图分类号]
[基金项目]
国家自然科学基金(81573216),研究生创新科研项目(2016YJSCX-23MY),牡丹江医学院科研项目(ZS201518)