目的评价壳聚糖对临床手术创面修复的有效性及安全性。方法检索Cochrane图书馆临床对照试验资料库（CCTR）,Medline、Embase、PubMed数据库,中国期刊全文数据库（CNKI）、万方数字化期刊全文库、中文科技期刊全文数据库（VIP）和中文生物医学期刊文献库（CMCC）,收集壳聚糖修复手术创面的随机对照临床试验,使用RevMan 5.0软件进行Meta分析。结果共纳入16项研究,3 414例患者。Meta分析结果显示：壳聚糖对手术创面修复的愈合时间明显短于对照组[WMD=-0.64,95%CI（-0.69~-0.59）,P<0.000 01],且能更好地促进切口愈合[RR=1.03,95%CI（1.01~1.04）,P=0.0002]；明显减轻术后疼痛[WMD=-3.49,95%CI（-5.07~-1.91）,P<0.000 1]；减少术后感染[RR=0.49,95% CI：0.33~0.71,P=0.000 2]。结论壳聚糖能缩短术后伤口愈合时间,更好地促进伤口愈合,减轻疼痛,减少感染；但纳入的研究质量均不高,仍亟需更多高质量的临床试验进一步验证壳聚糖对临床手术后创面修复的有效性和安全性。

Objective To evaluate the efficacy and safety of chitosan in the repair of clinical surgery wounds. Methods The databases of Cochrane Controlled Trials Register (CCTR), Embase database, Medline database, PubMed database, CNKI database, WanFang database, VIP database and Chinese Biomedical Journal Library (CMCC) were retrieved with computer for collecting randomized controlled trials (RCT) about the repair clinical surgery wounds healing. Meta-analysis on all the data are carried out by RevMan 5.0 software. Results There were totally 16 trials and 3414 patients included. The results showed that the wound healing time of chitosan was significantly shorter than that of the control group[WMD=-0.64, 95%CI (-0.69~-0.59), P < 0.000 01], and chitosan can better promote wound healing[RR=1.03, 95%CI (1.01~1.04), P=0.0002]. In experimental group, postoperative pain were reliever[WMD=-3.49, 95%CI (-5.07~-1.91), P < 0.0001], and postoperative infection were reduced[RR=0.49, 95%CI (0.33~0.71), P=0.0002]. Conclusion The existing evidences indicate that chitosan can shorten postoperative wound healing time, promote wound healing, relieve pain, and reduce infection. However, the study is limited by the quality of included literature, more clinical trials should be done to confirm the effective and safety.

福建省科技厅高校产学合作项目（2015Y4006）；福建中医药大学校管课题（XB2015001）