目的观察稳心颗粒联合富马酸比索洛尔治疗心力衰竭合并室性早搏的临床疗效。方法选择2013年1月-2016年1月在兵团第七师医院收治的心力衰竭合并室性早搏的患者132例,随机分为两组,每组66例。富马酸比索洛尔组（BF组）患者接受富马酸比索洛尔治疗,口服5 mg/次,每天1次；稳心颗粒联合富马酸比索洛尔（BW）组患者在BF组治疗基础上服用稳心颗粒,温水冲服,9 g/次,每天3次,所有患者服用4周。监测患者心电图并进行心脏超声检查,同时测定患者治疗前后血浆氨基末端B型利钠肽前体（NT-proBNP）的浓度并测定血液流变学指标。结果比较两组患者治疗后的心脏超声结果,BW组患者的心室功能恢复情况明显优于BF组（P<0.05）；BW组患者临床症状、室性早搏、心衰疗效的总有效率较BF组更高（P<0.05）。BW组患者全血黏度、血浆黏度、血浆纤维蛋白原等血液流变学指标以及血浆NT-proBNP的浓度明显低于BF组（P<0.05）。结论稳心颗粒联合富马酸比索洛尔较富马酸比索洛尔单一用药治疗心力衰竭合并室性早搏临床疗效改善更显著,且用药相对安全。

Objective To explore the curative effect of bisoprolol fumarate combined with wenxin granule for patients with heart failure complicated with premature ventricular. Methods 132 patients with heart failure and premature ventricular complexes were enrolled in our hospital from January 2013 to January 2016, and which patients divided into two groups, bisoprolol fumarate group (Group BF, n=66) accepted bisoprolol fumarate treatment (5 mg/time, 1 times/day), and bisoprolol fumarate combined with wenxin granule group (Group BW n=66) adopted wenxin granule (9 g/time, 3 times/day) based on the patients in Group BF. After 4 weeks treatment, the curative effect of all patients were evaluated with electrocardiogram monitor and cardiac ultrasound examination, and the plasma NT-proBNP concentration and hemorheology indexes were analyzed compared with pre-treatment. Results The recovery of ventricular function in Group BW was better significantly than that patients in Group BF from the cardiac ultrasound examination (P < 0.05); The total relieved effective of clinical symptom, premature ventricular complexes and heart failure in Group BW were more remarkable than those in Group BF, and which difference from them was significance (P < 0.05); The blood viscosity, plasma viscosity, plasma fibrinogen and plasma NT-proBNP concentration in patients with Group BW were significantly lower than those Group BF (P < 0.05). Conclusions The clinical curative effect of bisoprolol fumarate combined with Wenxin Granule for heart failure complicated with premature ventricular was more remarkable compare with bisoprolol fumarate single treatment, and which possessed the relative safety.