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[摘要]
目的探讨重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗急性脑梗死合并心房颤动患者的价值。方法采用前瞻性研究方法,选择2015年2月-2016年8月在西电集团医院进行诊治的急性脑梗死患者74例,根据随机信封抽签原则分为观察组与对照组各37例。对照组应用尿激酶静脉溶栓治疗,观察组应用rt-PA静脉溶栓治疗,均治疗7 d。观察两组临床疗效、mRS评分及治疗后症状性脑出血与非症状性脑出血情况。结果观察组与对照组的治疗有效率分别为94.6%和75.7%,观察组的治疗有效率明显高于对照组(P<0.05)。治疗后观察组与对照组的mRS评分分别为(5.22±1.83)分和(7.29±1.45)分,都明显低于治疗前的(10.24±1.31)分和(10.19±1.52)分(P<0.05),且观察组评分明显低于对照组(P<0.05)。观察组的症状性脑出血与非症状性脑出血分别为5.4%和2.7%,都明显低于对照组的18.9%和16.2%(P<0.05)。结论 rt-PA静脉溶栓治疗急性脑梗死合并心房颤动患者是安全有效的,能促进神经功能的改善,有很好的应用价值。
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[Abstract]
Objective To investigate the values of recombinant tissue type plasminogen activator (rt-PA)) in the treatment of acute cerebral infarction complicated with atrial fibrillation.Methods Used the prospective research methods,74 patients of acerebral infarction complicated with atrial fibrillation in Xi'an XD Group Hospital from February 2015 to August 2016 were selected and were equally divided into the observation group and the control group accorded to the principle of random envelope drawing.The control group was treated with urokinase intravenous thrombolytic therapy,the observation group was treated with rt-PA intravenous thrombolytic therapy,and the prognosis of the two groups were observed.Results There were no significant differences in gender,age,time window,disease,systolic blood pressure and diastolic blood pressure compared between the two groups.The treatment efficiency in the observation group and control group were 94.6% and 75.7%,the observation group was significantly higher than that of the control group (P < 0.05).After treatment,the mRS scores in the observation group and the control group were (5.22±1.83) points and (7.29±1.45) points,were significantly lower than those before treatment of (10.24±1.31) points and (10.19 ±1.52) points (P < 0.05),and the observation group was significantly lower than the control group (P < 0.05).In the observation group,the symptomatic intracerebral hemorrhage and non symptomatic cerebral hemorrhage were 5.4% and 2.7% respectively,so that were 18.9% and 16.2% in the control group that the observation group were significantly lower than those of the control group (P < 0.05).Conclusion Intravenous thrombolysis with recombinant tissue type plasminogen activator of patients with acute cerebral infarction combined with atrial fibrillation is safe and effective,it can promote the improvement of neurological function, and has good application value.
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