目的探讨分析丁苯酞对急性脑梗死患者NT-proBNP水平和血清炎症因子的影响。方法选择2014年3月-2016年5月在衡水市第五人民医院神经内科接受治疗的118例急性脑梗死患者,随机分为对照组60例和观察组58例。对照组给予常规药物治疗,观察组在对照组的基础上给予丁苯酞注射液治疗。观察治疗前及治疗7、14 d后两组患者的血浆N末端B型脑钠肽前体（NT-proBNP）水平、美国国立卫生研究院卒中量表（NIHSS）和血清炎症因子包括超敏C反应蛋白（hypersensitiveC-reactive protein,hs-CRP）、白细胞介素-6（interleukin-6,IL-6）及肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）,以及不良反应发生情况。结果治疗前,两组患者的血浆NT-proBNP水平、NIHSS评分以及血清炎症因子水平比较差异无统计学意义。治疗7、14 d后,两组NT-proBNP水平、NIHSS评分均明显降低,与治疗前比较差异显著（P<0.05）；治疗7、14 d后,观察组的NT-proBNP水平显著低于对照组（P<0.05）；治疗14 d后,观察组的NIHSS评分显著低于对照组,比较差异具有统计学意义（P<0.05）。治疗前,两组的hs-CRP、IL-6、TNF-α比较差异无统计学意义；治疗7、14 d后,两组的hs-CRP、IL-6、TNF-α水平均明显降低,与治疗前比较差异显著（P<0.05）；且观察组的以上3个血清炎症因子水平均显著低于对照组,两组比较差异具有统计学意义（P<0.05）。结论丁苯酞可有效抑制急性脑梗死患者的血浆NT-proBNP水平及血清炎症因子水平,改善患者神经功能预后。

Objective To investigate the clinical efficacy of dl-3n-butylphthalide and its effect on NT-proBNP levels and inflammatory cytokines of patients with acute cerebral infarction. Methods Total 118 patients with acute cerebral infarction in Hengshui Fifth People's Hospital were randomly divided into control group and observation group. Sixty patients in control group were treated with conventional medication, and 58 patients in observation group were treated with dl-3n-butylphthalide injection based on conventional medication. The NT-proBNP levels, score of neurological deficits (NIHSS), inflammatory cytokines including hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) before and after 7 and 14 d of treatment, and adverse reaction were observed and analyzed. Results Before treatment, differences in the NT-proBNP levels, NIHSS score, hs-CRP, IL-6, and TNF-α between two groups were not obvious. After 7 and 14 d of treatment, NT-proBNP levels in observation group were significantly lower than those in control group (P < 0.05). And after treatment for 14 d, NIHSS score in observation group were conspicuously lower than those in control group (P < 0.05). Additionally, the levels of hs-CRP, IL-6, and TNF-α in observation group were markedly lower than those in control group (P < 0.05). Conclusion Dl-3n-butylphthalide injection has a good ability in inhibiting NT-proBNP levels and inflammatory cytokines, and improves the neurological function of patients with acute cerebral infarction.