多潘立酮是一种高效的外周多巴胺受体拮抗剂，能够作用于胃肠道，促进胃肠蠕动，协调胃与十二指肠运动，具有显著的胃动力和止吐效果，在临床上广泛应用。近年来，随着多潘立酮的广泛应用，一些严重的不良反应也暴露出来，其中最近引起关注的是心脏不良反应。介绍了目前临床应用中多潘立酮的适应症、配伍等方面的新认识，并对其致心脏不良反应的危险因素和发生机制进行阐述，旨在提高医务工作者和患者的用药安全意识，为临床合理用药提供依据。

Domperidone is an effective peripheral dopamine receptor antagonist. It can work on the gastrointestinal tract to promote gastrointestinal peristalsis and coordinate the movement of stomach and duodenum. Because of the significantly gastric motility and anti-nausea effect, domperidone was widely used in clinic. With the wide application, some serious adverse reactions of domperidone were also exposed recently. Among these, cardio-toxicity is the severest and it has attracted the attention. This paper introduces the new understanding of domperidone in the indications, drug compatibility in current clinical application and summarizes the risk factors and response mechanism of the cardiac adverse reactions. The purpose of this article is to improve medical workers and patients' medical security awareness and provide the basis for clinical rational drug use.

国家青年基金资助项目（31400979），山东省重点研发计划（2016GSF121039）