目的 探讨阿托伐他汀致不良反应的一般规律与特点，为临床合理用药提供参考。方法 回顾性对福建省长乐市医院2008年1月-2016年5月收集阿托伐他汀所致的ADR报告表进行统计、分析。结果 阿托伐他汀引起的不良反应共计52例。所致不良反应发生次数最多为肝胆系统损害22次（37.29%），胃肠系统损害11次（18.64%），全身性损害5次（8.47%），肌肉骨骼系统损害5次（8.47%），心肌、心内膜、心包及瓣膜损害4次（6.78%），听觉和前庭功能损害4次（6.78%）。结论 临床上应加强阿托伐他汀应用的监测，以减少不良反应的发生。

Objective To explore the general rules and characteristics of adverse reactions induced by atorvastatin, and to provide reference for clinical rational use of drugs. Method A retrospective analysis was made on the statistics and analysis of the ADR report forms collected in Fujian Changle Hospital from January 2008 to May 2016. Results The adverse reactions induced by atorvastatin were 52 cases. The number of adverse reactions was up to a maximum of hepatobiliary system damage 22 times (37.29%), gastrointestinal system damage 11 times (18.64%), systemic damage 5 times (8.47%), musculoskeletal system damage 5 times (8.47%), myocardium, endocardium, pericardial and valvular damage 4 times (6.78%), auditory and vestibular function damage 4 times (6.78%). Conclusion The clinical application of atorvastatin should be strengthened in order to reduce the occurrence of adverse reactions.