目的 探究氧驱动雾化吸入普米克令舒联合孟鲁司特治疗小儿哮喘的有效性及对肺功能、T淋巴细胞亚群的影响。方法 选择惠州市中心人民医院2014年6月-2016年6月收治的78例小儿哮喘患者，根据随机数字表法，分为观察组和对照组，每组39例。对照组在常规治疗基础上以氧驱动雾化吸入普米克令舒1.0 mg，2次/d，观察组在对照组基础上再加服孟鲁司特钠咀嚼片5 mg/次，1次/d，1周为1个疗程。比较两组患者临床疗效、症状评分、肺功能、细胞免疫水平。结果 观察组的总有效率为94.70%，显著高于对照组的总有效率82.05%（P<0.05）；治疗后，两组患儿症状评分均显著降低（P<0.05），且观察组的症状评分显著低于对照组（P<0.05）；两组患儿的肺功能均有明显改善，且观察组患者的FEV1、FVC以及FEV1/FVC水平显著高于对照组（P<0.05）；对照组的细胞免疫水平无明显改善，观察组患者的CD₄⁺以及CD₄⁺/CD₈⁺水平与治疗前相比均明显降低，CD₈⁺水平显著提升（P<0.05）。结论 氧驱动雾化吸入普米克令舒联合孟鲁司特治疗小儿哮喘临床效果显著，对机体免疫水平具有正向调节作用，值得临床推广。

Objective To explore the validity of oxygen atomizing inhalation pulmicort respulas combined with montelukast in treating children with asthma and its role in pulmonary function and T lymphocyte subset. Methods Totally 78 cases treated in Huizhou People's Hospital from June, 2014 to June, 2016 were randomly divided into observation group and control group with each group of 39 cases. The control group on the basis of routine treatment with oxygen atomizing inhalation of pulmicort 1 mg, twice daily, and the observation group based on control group added Montelukast Sodium Chewable Tablets 5 mg, once daily, one week for one course. The clinical effect, pulmonary function, and level of T lymphocyte subset were compared between two groups. Results The total effective rate in the observation group was 94.70%, which was significantly higher than control group (82.05%, P<0.05). After therapy, the symptom scores of two groups were obviously decreased compared with those before therapy (P<0.05), and those of the observation group were significantly lower than control group (P<0.05); The pulmonary function of the two groups were obviously improved (P<0.05) compared with that before therapy (P<0.05), and the levels of FEV1, FVC, and FEV1/FVC in observation group were significantly higher than control group (P<0.05); The level of T lymphocyte subset in control group showed no statistical difference compared to that before therapy, and the levels of CD₄⁺and CD₄⁺/CD₈⁺in observation group were obviously decreased, whereas CD₈⁺was increased. Conclusion Oxygen atomizing inhalation pulmicort respulas combined with montelukast could effectively increase the clinical effect on children with asthma, improve pulmonary function and positively regulate immune function, which deserves clinical expansion.