目的 探讨分析冻干重组人脑利钠肽对心肌梗死合并心力衰竭患者血管内皮功能和炎症因子的影响。方法 选择2012年3月-2016年3月汉中市中心医院收治的266例心肌梗死合并心力衰竭患者，随机分为对照组（128例）和观察组（138例）。对照组给予常规药物治疗，观察组在对照组的基础上静脉滴注冻干重组人脑利钠肽3～5 d。观察比较两组患者的血管内皮功能、炎症因子的变化，以及治疗总有效率。结果 治疗后2周，观察组患者的内皮依赖性血管舒张功能（FMD）显著高于对照组（P<0.05）；观察组的血清NO显著高于对照组，内皮素1显著低于对照组（P<0.05）；治疗5 d后，观察组患者的血清C反应蛋白（CRP）、白细胞介素-6（IL-6）及血清肿瘤坏死因子（TNF-α）均显著低于对照组，差异具有统计学意义（P<0.05）；观察组患者的治疗总有效率为89.1%，显著高于对照组的60.2%，两组比较差异具有统计学意义（P<0.05）。结论 冻干重组人脑利钠肽可促进血清NO的升高，抑制内皮素1的升高，利于心肌梗死合并心力衰竭患者血管内皮功能的改善，抑制炎症因子的释放而进一步改善其心功能。

Objective To investigate the effect of natriuretic peptide on vascular endothelial function and inflammatory factors of patients with heart failure complicating myocardial infarction. Methods Two hundred and twenty-six patients with heart failure complicating myocardial infarction admitted into Hanzhong Central Hospital from March 2012 to March 2016 were randomly divided into experimental group (n=138) and control group (n=128). Patients in control group were treated with conventional drug, and patients in experimental group were treated with natriuretic peptide based on conventional drug treatment. The vascular endothelial function, contents of NO and eddthelin 1, and inflammatory factors including CRP, IL-6, and TNF-α were detected. Results After 2 weeks of treatment, the flow-mediated vasodilation (FMD) and NO in experimental group were remarkably higher than those in control group, and eddthelin 1 was significantly lower than those of control group (P<0.05). Additionally, CRP, IL-6, and TNF-α in experimental group were significantly lower than those in control group after treatment for 5 d (P<0.05). Conclusion Natriuretic peptide could improve the vascular endothelial function of patients with heart failure complicating myocardial infarction via increasing the content of NO and decreasing content of eddthelin 1, and was benefit to cardiac function by inhibiting release of inflammatory factors.