目的 观察消旋卡多曲颗粒联合炎琥宁注射液对轮状病毒肠炎（RVE）患儿心肌的保护作用，探讨其相关的作用机制和临床疗效。方法 选取鄂东医疗集团黄石市中医医院2013年12月-2016年6月治疗的RVE患儿116例，随机分为消旋卡多曲颗粒对照组和消旋卡多曲颗粒联合炎琥宁注射液观察组，每组58例。使用ELISA法测定肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）、白介素-17（IL-17）、白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α），比较两组的临床有效率和不良反应。结果 治疗前两组CK、CK-MB、LDH、IL17、IL-6和TNF-α表达无显著性差异，治疗后两组上述指标均显著降低（P<0.05、0.01），但观察组对上述指标的减低作用显著高于对照组（P<0.05）。观察组临床治疗有效率为94.8%，显著高于对照组的81.0%（P<0.05）。观察组临床治疗不良反应率为8.6%，对照组的不良反应率为6.9%，两组比较无显著性差异。结论 消旋卡多曲颗粒联合炎琥宁注射液治疗小儿轮状病毒肠炎可以抑制炎症反应，保护患儿心肌损伤，临床疗效显著，且使用安全。

Objective To observe the protective effect of Racecadotril combined with Succinate Injection on myocardial injury in children with rotavirus enteritis and explore its clinical significance.Methods Totally 116 cases of children with rotavirus enteritis from Huangshi Traditional Chinese Medicine of Edong Healthcare Group were selected in this study. Patients were randomly divided into Racecadotril control group (n=58) and Racecadotril combined with Succinate Injection observation group (n=58). The levels of CK, CK-MB, LDH, IL-17, IL-6, and TNF-α were detected by ELISA analysis. The rates of clinic effects and adverse reaction were compared.Results There was no significant difference of CK, CK-MB, LDH, IL-17, IL-6, and TNF-α between two groups before treatment. After treatment, they were all decreased in two groups (P<0.05, 0.01). However, they were all lower in observation group than those in control group after treatment (P<0.05). The rate of clinic effects was 94.8% in observation group, which was higher than 81.0% in control group (P<0.05). The rate of adverse reaction was 8.6% in observation group and 6.9% in control group. There was no significant difference between two groups.Conclusion Racecadotril combined with Succinate Injection inhibits the inflammatory response to protect myocardial injury in RVE children, with significantly clinical efficacy and safety.