目的 探讨泮托拉唑与奥曲肽治疗上消化道出血的疗效。方法 选取了220例上消化道出血患者，按随机数字表法分为两组，观察组（115例）给予奥曲肽联合泮托拉唑治疗，对照组（105例）给予泮托拉唑治疗，观察两组疗效、围手术期指标、SF-36评分及随访1个月期间不良反应情况，评价泮托拉唑与奥曲肽治疗上消化道出血的疗效。结果 治疗后观察组有效率明显高于对照组（P<0.05），观察组出血时间短于对照组，输血量少于对照组；血红蛋白水平，胃液PH值显著高于对照组（P<0.05），治疗前，两组SF-36量表各项评分相比，无统计学差异。治疗后1个月，观察组在生理功能、生理职能、躯体疼痛上评分均明显高于对照组（P<0.05），其余各项评分相比无统计学差异，随访1个月期间，两组不良反应无统计学差异。结论 奥曲肽联合泮托拉唑对上消化道出血具有较好疗效，能够迅速止血，减少血液流失和输血量，改善患者生活质量，用药具有安全性，值得临床推广使用。

Objective Discuss the efficacy of pantoprazole and octreotide in treatment of gastrointestinal hemorrhage.Methods Selecting 220 cases patients with gastrointestinal hemorrhage. They were divided into two groups randomly. The observation group (115 cases) was given pantoprazole combined with octreotide. The observation group (105 cases) was given pantoprazole. The efficacy of pantoprazole and octreotide in treatment of gastrointestinal hemorrhage was evaluated by efficacy, perioperative index, SF-36 scores and adverse reaction during 1 month follow-up.Results The effective rate of observation group was significantly higher than that of the control group (P<0.05). The bleeding time of observation group was shorter than that of control group (P<0.05). The blood transfusion of observation group was less than that of control group (P<0.05). The hemoglobin level and PH value observation group was higher than that of control group (P<0.05). Before treatment, there were no statistical significance on SF-36 scores. After 1 months treatment, physiological function, physical function and pain scores of observation group was higher than that of control group (P<0.05). During 1 months follow-up, there were no statistical significance on adverse reaction between two groups.Conclusion The pantoprazole combined with octreotide had a good therapeutic effect on gastrointestinal hemorrhage. It could stop bleeding quickly, reduce blood loss and blood transfusion. It could improve the quality of life and use safely with worthy of clinical use.