目的 观察白脉软膏对脑卒中的预防和治疗作用，并对其可能的活血化瘀治疗原则进行初步探究。方法 白脉软膏皮肤外涂给药，高、中、低剂量分别为0.075、0.150、0.300 g生药/kg，采用大鼠脑中动脉血栓性局部缺血模型评价白脉软膏的预防和治疗作用；采用大鼠自身血肿吸收实验、大鼠急性血瘀模型和大鼠实验性体内血栓形成实验评价白脉软膏活血化瘀作用。结果 白脉软膏皮肤外涂给药，在0.075、0.150、0.300 g生药/kg剂量下，对脑卒中模型大鼠无显著预防作用；显著改善脑卒中模型大鼠行为学评分；显著减小大鼠自身血肿面积；显著降低血瘀模型大鼠全血黏度及血浆黏度；显著的延长大鼠颈动脉血栓形成时间。结论 白脉软膏能够显著改善脑卒中模型大鼠行为协调性，发挥显著治疗作用，但并无显著预防作用，初步探明其可能的中医治疗原则为活血化瘀。

Objective To observe the preventive and therapeutic effect of Baimai Ointment on stoke, and explore the principle of promoting blood circulation and removing blood stasis.Method By dermal administration, the crude drug contents of Baimai Ointment given to rats were 0.075, 0.150, and 0.300 g/kg respectively. Focal cerebral ischemic model was induced by the middle cerebral artery occlusion (MCAO), and the preventive and therapeutic effect of Baimai Ointment was evaluated. The degree of hematoma absorption in rats was measured to observe the effect on promoting blood circulation and removing blood stasis of Baimai Ointmnent. The acute blood stasis model and carotid thrombosis model were established in rats to study the effects on blood viscosity and thrombosis time.Results Baimai Ointment had no significant prevent effect on stroke in rats. It effectively improved behavior coordination in stroke model rats. It also significantly decreased the area of hematoma on rats, speeded up the repairment of local demage. After administration of Baimai Ointment, blood viscosity of blood stasis model rats was obviously decreased, while thrombosis time was effectively prolonged on carotid thrombosis model.Conclusion Baimai Ointment can significantly improve the behavior coordination in stroke model rats, plays a significant role in treatment, but no significant preventive effect, a preliminary study shows that the possible therapeutic principles may be promoting blood circulation and removing blood stasis.