目的 研究含对乙酰氨基酚的西药对乙酰氨基酚片、复方氨酚烷胺片、美扑伪麻片及中成药柴芩清宁胶囊对脂多糖（LPS）及干酵母大鼠发热模型的解热作用。方法 制备大鼠100 μg/kg LPS及20%干酵母发热模型；乙酰氨基酚片、复方氨酚烷胺片、美扑伪麻片高、中、低剂量分别为205.67、102.83、51.42 mg/kg，以对乙酰氨基酚计；柴芩清宁胶囊高、中、低剂量分别为1110.60、555.30、277.65 mg/kg，以胶囊内容物质量表示，ig给药。观察大鼠体温变化，计算平均最大体温上升高度（△T）及体温反应指数（TRI），绘制平均升温曲线。结果 对乙酰氨基酚片、复方氨酚烷胺片、美扑伪麻片及柴芩清宁胶囊各剂量组对LPS及干酵母大鼠发热模型均具有显著解热作用，且均存在一定剂量效应关系。结论 对乙酰氨基酚片、复方氨酚烷胺片、美扑伪麻片及柴芩清宁胶囊对LPS及干酵母大鼠发热模型均有一定解热作用，3种西药的解热作用起效快但是作用时间短，而柴芩清宁胶囊表现为起效慢但是作用时间长。

Objective To study the antipyretic effect of Paracetamol Tablets, Compound Paracetamol and Amantadine Hydrochloride Tablets, Compound Dextromethorphan Hydrobromide Tablets, and Chaiqin Qingning Capsules on the fever model induced by LPS and dry yeast in rats.Methods Fever was induced by ip injecting LPS (100 μg/kg) or sc injecting dry yeast (20%) in rats. We observed the changes of temperature of the rats after administration of Paracetamol Tablets, Compound Paracetamol and Amantadine Hydrochloride Tablets, Compound Dextromethorphan Hydrobromide Tablets (the acetaminophen contents were 205.67, 102.83, and 51.42 mg/kg) and Chaiqin Qingning Capsules (1110.60, 555.30, and 277.65 mg/kg). Maximum temperature rise height (△T) and temperature response index (TRI) were calculated, and the curve of average rise in temperature was drawn.Results Each dose group of Paracetamol Tablets, Compound Paracetamol and Amantadine Hydrochloride Tablets, Compound Dextromethorphan Hydrobromide Tablets, and Chaiqin Qingning Capsules had obvious antipyretic effect on the fever model induced by LPS and dry yeast in rats, and there was a certain dose-effect relationship.Conclusion Paracetamol Tablets, Compound Paracetamol and Amantadine Hydrochloride Tablets, Compound Dextromethorphan Hydrobromide Tablets, and Chaiqin Qingning Capsules has certain antipyretic effect on LPS and dry yeast fever model in rats, and on the whole, the Western medicine acts rapid but continue for a short time, while the traditional Chinese medicine acts slow but continues for a long time.