目的 探讨医用臭氧关节腔注射联合独一味滴丸治疗膝骨关节炎的疗效。方法 选取80例膝骨关节炎患者，随机分为2组，对照组（39例）口服独一味滴丸治疗，观察组（41例）在口服独一味滴丸的基础上关节腔内注射医用臭氧，观察并记录两组患者治疗后的疗效、膝关节功能、炎性因子变化情况，评价独一味滴丸联合医用臭氧关节腔注射治疗膝骨关节炎的疗效。结果 治疗后观察组有效率明显高于对照组（P<0.05），观察组中有38例患者治疗后膝关节疼痛减轻，压痛和肿胀症状有所缓解，对照组有28例。治疗后观察组在疼痛度、活动度、行走能力评分及美国膝关节协会评分（KSS）总分方面，均明显高于对照组（P<0.05）；在稳定性评分上相比，差异没有统计学意义。治疗前，两组在IL-6、IL-8、TNF-α相比，差异没有统计学意义；治疗后，两组IL-6、IL-8、TNF-α水平均明显降低（P<0.05），且观察组在上述指标中均明显低于对照组（P<0.05）。结论 医用臭氧关节腔注射联合独一味滴丸治疗膝骨性关节炎具有较好的治疗作用，能明显缓解膝关节疼痛，提高膝关节功能，抗炎作用强，值得临床推广使用。

Objective To discuss the efficacy of Lamiophlomisrotata Dripping Pill combined with intra-articular injection of medical ozone in the treatment of knee osteoarthritis. Methods Eighty patients with knee osteoarthritis were selected, the control group (39 cases) were administered Lamiophlomisrotata Dripping Pill, the observation group (41 cases) were administered Lamiophlomisrotata Dripping Pill combined with intra-articular injection of medical ozone. The efficacy of Lamiophlomisrotata Dripping Pill combined with intra-articular injection of medical ozone in the treatment of knee osteoarthritis were evaluated by efficacy, knee function, and inflammatory factor. Results After treatment, the effective rate of the observation group was higher than that of the control group (P<0.05). In the observation group, there were 38 cases of patients who felt pain, tenderness, and swelling symptom relief. There were 28 cases in the control group. After treatment, the scores of pain, activity, walking ability, and KSS in the observation group were higher than that of the control group (P<0.05). There was no statistical significance on the stability between two groups. Before treatment, there were no statistical significance on the IL-6, IL-8, and TNF-α. After treatment, the IL-6, IL-8, and TNF-α were increased in two groups (P<0.05). And these indexes in the observation group were higher than that of the control group (P<0.05). Conclusion In summary, Lamiophlomisrotata Dripping Pill combined with medical ozone had good effect on the knee osteoarthritis. It could release the pain, improve knee function and anti-inflammatory. It was worthy of clinical use.