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[摘要]
目的 对比分析顺铂或奈达铂与紫醇联合治疗宫颈癌的疗效。方法 选择2012年2月-2015年12月在宁强县天津医院进行诊治的宫颈癌患者160例,按照使用化疗药物的不同分为顺铂组和奈达铂组。顺铂组采取TP化疗方案,奈达铂组采取TN化疗方案,对比两组的疗效、化疗不良反应、住院时间和治疗费用。结果 顺铂组的有效率为79.26%,与奈达铂组的82.05%相比无明显差异;奈达铂组Ⅰ~Ⅳ级血红蛋白降低、白细胞减少的发生率均明显高于顺铂组(P<0.05),但两组间Ⅲ~Ⅳ级血红蛋白降低、血小板和白细胞减少发生率无明显差异,奈达铂组Ⅰ~Ⅳ级和Ⅲ~Ⅳ级恶心、呕吐发生率均明显低于顺铂组(P<0.05);奈达铂组患者的住院时间明显短于顺铂组(P<0.05);奈达铂组的治疗费用与顺铂组相比无明显差异。结论 顺铂或奈达铂与紫杉醇联合应用于宫颈癌辅助化疗的疗效相似,奈达铂的胃肠道不良反应比顺铂更低,骨髓抑制尽管增加但仍可控,采用奈达铂化疗较顺铂缩短了住院时间,且住院费用并无明显增加,患者更易接受。
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[Abstract]
Objective To compare the effect of cisplatin or nedaplatin combined with paclitaxel as an adjuvant chemotherapy for cervical cancer. Methods Total 160 patients with cervical cancer in Ningqiang County Tianjin Hospital from February 2011 to December 2015 were divided into two groups according to different treatments. Cisplatin group was treated with TP chemotherapy, nedaplatin group was treated with TN chemotherapy, the curative effect, adverse reaction of chemotherapy, hospitalization time and treatment costs were compared between the two groups. Results The effective rate of cisplatin group was 79.26% and nedaplatin group's was 82.05%, the two groups had no significant difference; The incidence of I-IV grade hemoglobin, leukocyte of nedaplatin group were significantly higher than those in the cisplatin group (P<0.05), but between the two groups Ⅲ and IV grade had no significant difference, the incidence of I-IV grade and Ⅲ-IV grade nausea, vomiting of nedaplatin group were significantly lower than cisplatin group (P<0.05); The hospitalization time of nedaplatin group was significantly shorter than cisplatin group (P<0.05), The cost of treatment between nedaplatin group and cisplatin group had no significant difference. Conclusion Cisplatin or nedaplatin combined with paclitaxel has similar efficacy in the neoadjuvant chemotherapy for cervical cancer, gastrointestinal adverse reactions of nedaplatin are lower than cisplatin, bone marrow suppression increase but still can be controlled, nedaplatin chemotherapy can shorten the duration of hospitalization, and hospitalization expenses were not significantly increased, which makes it more easily accepted by patients.
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