目的 观察气滞胃痛颗粒联合雷贝拉唑对反流性食管炎（RE）患者胃动力调节激素以及炎症因子的影响，并探讨相关的临床意义。方法 选取2013年2月－2016年2月北京市昌平区中医院收治的RE患者96例，随机分为对照组和观察组，各48例。对照组服用雷贝拉唑钠肠溶片10 mg/次、2次/d，观察组在对照组基础上加用气滞胃痛颗粒5 g/次、3次/d，均4周为1疗程。放射免疫法检测胃泌素、胃动素表达，酶联免疫法测定白介素-17（IL-17）和白介素-23（IL-23）表达。比较两组治疗后有效率和不良反应发生率。结果 治疗前对照组和观察组的胃泌素和胃动素表达无显著差异，治疗后两组的表达均显著升高（P<0.05、0.01），但治疗后观察组的胃泌素和胃动素表达显著高于对照组（P<0.05）。治疗前对照组和观察组IL-17和IL-23表达无显著差异，治疗后两组的表达均显著减低（P<0.05、0.01），但治疗后观察组的IL-17和IL-23表达显著低于对照组（P<0.05）。观察组和对照组临床治疗有效率分别为93.8%和81.3%，观察组有效率显著高于对照组（P<0.05）。对照组不良反应率为10.4%，观察组的为8.3%，两组比较无显著差异。结论 气滞胃痛颗粒联合雷贝拉唑可以改善反流性食管炎患者胃-食管动力、抑制炎症反应，疗效显著，且使用安全。

Objective To observe the effect of Qizhi Weitong Granules combined with rabeprazole on gastroesophageal dynamics and inflammatory factors in reflux esophagitis (RE) and explore its clinical significance. Methods Nighty-six RE patients from Changping Chinese Medicine Hospital were selected in this study, which randomly divided into control group (n=48) and observation group (n=48). The control group was given rabeprazole 10 mg/time (2 times/d) for 4 weeks. The observation group was given rabeprazole 10 mg/time (2 times/d) and Qizhi Weitong Granule 5 g/time (3 times/d) for 4 weeks. The gastrin and motilin expression was detected by radioimmunity analysis. The IL-17 and IL-23 was detected by ELISA analysis. The rate of clinic effects and adverse reaction was compared. Results There was no significant difference of gastrin and motilin between the two groups before treatment. After treatment, gastrin and motilin was increased in the two groups (P<0.05, 0.01). However, gastrin and motilin was higher in observation group than that in control group after treatment (P<0.05). There was no significant difference of IL-17 and IL-23 between two groups before treatment. After treatment, IL-17 and IL-23 was decreased in the two groups (P<0.05, 0.01). However, IL-17 and IL-23 was lower in observation group than that in control group after treatment (P<0.05). The rate of clinic effects was 93.8% in observation group, which was better than 81.3% in control group (P<0.05). The rate of adverse reaction was 10.4% in control group and 8.3% in observation group. There was no significant difference between two groups. Conclusion Qizhi Weitong Granules combined with rabeprazole can improve gastroesophageal dynamics and inhibit inflammatory response in RE patients, with significantly clinical effect and safety.