朱砂为我国常用药材，主要成分为硫化汞（HgS）。由于汞为剧毒化合物，因此朱砂及其相关成药的安全问题一直备受关注。查阅现有文献，归纳总结朱砂及其制剂中汞的分析研究进展，包括总汞、单质汞、可溶性汞的测定及形态分析；并探讨了现有技术的特点，并对今后的发展做出展望，为朱砂及其制剂的科学评价和合理应用提供参考。

Cinnabar is a commonly used medicinal material in China. Its main gradient is HgS. Since mercury is an extremely poisonous compound, safety of cinnabar and its preparations has always been a matter of great concern. Based on literature review, research development of analysis of mercury in cinnabar and its preparations was summarized, including determination of total mercury, elemental mercury, and soluble mercury as well as analysis of the speciation states. Characteristics of the current technologies were discussed and the development trend was prospected. Reference was offered for scientific evaluation and rational use of cinnabar and its preparations.

国家自然科学基金资助项目（81303194）；国家重大新药创制专项（2014ZX09304307-002）