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[摘要]
目的 探讨吡格列酮对2型糖尿病周围神经病变患者血尿酸变化的影响。方法 收集2014年7月-2015年7月在南通市通州区第三人民医院住院并确诊患有糖尿病周围神经病变的患者80例,随机分为对照组和观察组各40例,两组患者均进行饮食控制结合运动疗法等一般治疗方式。对照组给予二甲双胍治疗,0.5 g/次,每日3次。观察组在对照组的基础上给予吡格列酮治疗,吡格列酮剂量为15 mg/次,每日1次。两组服药时间均为2个月。结果 两组空腹血糖及餐后2 h血糖浓度经治疗后均降低,观察组低于对照组(P<0.05);对照组治疗前后血尿酸差异无明显变化(P>0.05),观察组治疗后血尿酸浓度显著降低(P<0.05);两组治疗后CSS评分均低于治疗前评分(P<0.05);治疗后观察组评分低于对照组(P<0.05)。结论 吡格列酮联合二甲双胍对治疗2型糖尿病周围神经病变有一定疗效,可降低2型糖尿病周围神经病变患者血尿酸水平。
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[Abstract]
Objective To investigate the correlation of pioglitazone on serum uric acid in patients with type 2 diabetic peripheral neuropathy. Methods Totally 80 cases of patients diagnosed with type 2 diabetic peripheral neuropathy from July 2014 to July 2015 in the Third People's Hospital of Tongzhou were collected and randomly and averagely divided into control group and observation group. The two groups were both given diet intervention and sports therapy. Then the patients in control group were given Metformin treatment, 0.5 g every time, three times daily. The patients in observation group were given the same treatment as in control group and meanwhile given pioglitazone treatment, 15 mg every time, once daily. Both groups were given treatment for 2 months. Results The fasting blood glucose and postprandial 2 h blood glucose concentration were lower after treatment in both groups, and the level in observation was lower than that in the control group, (P<0.05); The changes of blood uric acid in the control group showed no obvious difference after treatment (P > 0.05),and the changes in observation group decreased after treatment (P<0.05); After treatment, the CSS grade in two groups was lower than before (P<0.05), and the score in observation group was lower than that in control group (P<0.05). Conclusion Pioglitazone combined with metformin shows certain curative effect for type 2 diabetic peripheral neuropathy and can reduce uric acid level in patients with type 2 diabetic peripheral neuropathy.
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