[关键词]
[摘要]
正常组织中用于供能的脂肪酸主要来自饮食中的游离脂质,但在生长旺盛的肿瘤组织中,能量却来自于脂质的重新合成,所以在不同来源的肿瘤组织中见到脂质合成相关基因的变化,在原发肿瘤中和肿瘤发生相关的生脂基因功能已经基本明确。研究表明在肿瘤细胞中脂肪酸合成酶,硬脂酰辅酶A脱氢酶1、乙酰辅酶A羧化酶在肿瘤的生成和发展起非常重要的作用。脂肪酸的功能与能量贮存、生物膜的结构、信号转导和蛋白质的乙酰化有关,但是现在对脂肪重新生成进程在肿瘤转移中的作用尚不明确。由于耐药性的产生和化疗药物的毒副反应,恶性肿瘤的化疗效果一直不满意,为了寻找新的、选择性抗肿瘤方法,以脂代谢催化酶为靶点的抗肿瘤药物亟待进一步研究和应用。
[Key word]
[Abstract]
The fatty acids in normal tissues for energy supply are mainly from dietary free lipid. However, in fast-developing tumor tissues, energy is supplied by lipid resynthesis, which explains why resynthesis-related genes are spotted in tumors of various origins. And the functions of the lipogenesis genes concerning the onset of primary tumors have been basically clear. A great number of studies have indicated that intracellular fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD1), and acetyl-CoA carboxylase (ACC) all play important roles in the genesis and development of tumors. The functions of fatty acids regard energy reserve, biomembrane structure, signal transduction, and protein acetylation. But unfortunately, the effect of lipid resynthesis on tumor metastasis remains unclear. The curative effect of chemotherapy in malignant tumors has been unsatisfactory because of drug resistance and the toxicity of chemotherapeutic drugs. In order to find new and selective antitumor methods, anticancer drugs targeting lipid metabolism catalyzing enzyme are urgently to be further studied and applied.
[中图分类号]
[基金项目]
国家自然科学基金项目面上项目(81472281)