目的 用莫西沙星、特非那定和卡托普利对犬植入式生物遥测技术进行性能评价研究。方法 4只埋植有遥测植入子的清醒Beagle犬，通过拉丁方设计，在4个不同的给药日分别ig给予空白胶囊、莫西沙星、特非那定和卡托普利30 mg/kg，用DSI遥测系统连续采集给药前2 h至给药后24 h的生理信号，对心电、血压、体温等数据进行分析，比较给药前与给药后各时间点各指标的差异。结果 空白胶囊对犬的各项生理指标无明显影响；给予莫西沙星和特非那定后，犬QT间期及校正的QT间期（QTc）与给药前比较，出现不同程度的延长；给予卡托普利对犬的心电参数无影响但显著降低血压。结论 植入式生物遥测技术可灵敏的检测到药物对清醒犬心血管系统的影响，可用于安全药理研究和清醒犬心血管模型研究。

Objective To evaluate the canine telemetry assay using moxifloxacin, terfenadine, and captopril. Methods Four conscious Beagle's dogs were instrumented with implantable telemetry devices for the measurement of blood pressure, ECG, and body temperature. Dogs were administered with blank capsules, moxifloxacin, terfenadine, and captopril in four different days using a 4×4 Latin's square design. The cardiovascular parameters were collected from 2 h before dosing to 24 h post-dosing. Results Blank capsules showed no significant effect on cardiovascular parameters. Moxifloxacin and terfenadine induced different prolongation on QT interval and corrected QT interval (QTc). Captopril had no effect on the ECG but reduced blood pressure significantly. Conclusion Telemetry assay is recommended as a sensitive test system for safety pharmacology evaluation and canine cardiovascular model which can detect the impact of drugs on the cardiovascular system.

建立符合国际标准的临床前药理毒理CRO外包服务平台（201300000053）；生理信号遥测系统在药物非临床评价中的应用研究（穗科条【2009】5-11）