目的 探讨5-氟尿嘧啶(5-Fu)联合甲氨蝶呤治疗恶性滋养细胞肿瘤的临床疗效。方法 以入院病例号为编号,根据随机数字表法,将80名确诊为恶性滋养细胞肿瘤的患者随机分成两组,每组40例。对照组给予5-Fu化疗;观察组给予5-Fu联合甲氨蝶呤治疗。观察两组患者治疗后血人绒毛膜促性腺激素(HCG)变化、临床症状缓解情况、疗效及不良反应等指标变化情况,探讨其临床治疗价值。结果 治疗后,观察组临床有效率为97.5%,明显高于对照组的85.0%,两组比较差异有统计学意义(P<0.05)。治疗后,观察组血HCG最高滴定值<10³ mIU/mL患者数为8例,明显高于对照组的4例,两组比较差异有统计学意义(P<0.05);观察组血HCG最高滴定值>10⁵ mIU/mL患者数为6例,明显低于对照组的18例,两组比较差异有统计学意义(P<0.05)。两组患者不同程度出现白细胞减少、恶心、呕吐、口腔溃疡等不良反应,但组间差异无统计学意义。结论 5-Fu联合甲氨蝶呤治疗恶性滋养细胞肿瘤疗效确切且安全可靠,值得临床推广应用。

Objective To investigate the clinical efficacy of 5-fluorouracil (5-Fu) combined with methotrexate in the treatment of malignant trophoblastic tumor. Methods Taking admission number as number, according to the random number table, 80 patients diagnosed as malignant tumor were randomly divided into two groups, 40 cases in each group. Patients in control group were treated with 5-Fu chemotherapy; Patients in observation group were treated with 5-Fu combined with methotrexate. The changes of blood HCG, clinical symptoms, efficacy, and adverse reactions of two groups of patients after treatment were observed. Results After treatment, the clinical effective rate of observation group (97.5%) was significantly higher than that in the control group (85%) (P<0.05). After treatment, the number of patients with the highest HCG value of blood less than 10³ mIU/mL in observation group (8 cases) were significantly higher than the control group (4 cases) (P<0.05); The number of patients with the highest HCG value of blood more than 10⁵ mIU/mL in the observation group (6 cases) was significantly lower than that in the control group (18 cases) (P<0.05). There were different degree of adverse reactions in patients with leukopenia, nausea, vomiting, oral ulcer, but no significant difference between the groups. Conclusion 5-Fu combined with methotrexate is effective and safe in the treatment of malignant tumor. It is worthy of clinical application.