目的 考察吉非替尼(GFB)脂质体对S180荷瘤小鼠生存时间及生命质量的影响。方法 30只小鼠制备S180荷瘤模型,随机分为5组:模型组,GFB低、高剂量溶液(GFB-S-20、GFB-S-40)组,GFB低、高剂量脂质体(GFB-L-20、GFB-L-40)组,低、高剂量为20、40 mg/kg。观察荷瘤小鼠的生存时间、体质量和肿瘤体积的增长情况,并以为自主活动次数为指标,评价小鼠的生命质量。结果 与模型组比较,GFB组的生存时间明显延长(P<0.05、0.01),GFB-L-40组生存时间显著长于GFB-S-40组(P<0.05);模型组小鼠体质量增长最快;肿瘤生长速度大小顺序为:模型组> GFB-S-20组> GFB-S-40组> GFB-L-20组> GFB-L-40组;GFB显著改善荷瘤小鼠自主活动次数下降,相同剂量的溶液和脂质体组之间存在显著性差异(P<0.05)。结论 GFB脂质体明显延长了S180荷瘤小鼠的生存时间,提高了生命质量,效果优于溶液组。

Objective To investigate the effects of gefitinib (GFB) liposomes on survival and quality of life of mice bearing S180 tumor. Methods The animal model bearing S180 tumor was established in 30 mice. The mice were randomly divided into five groups:model group, low-, high-dose GFB (GFB-S-20, GFB-S-40) groups, and low-, high-dose GFB liposomes (GFB-L-20, GFB-L-40) groups, and the administration of GFB solutions and GFB liposomes were 20 and 40 mg/kg. The growth and survival of mice bearing S180 tumor were observed for statistical analysis. The number of autonomic activity was used as indiactor to evaluate the quality of life of S180 tumor-bearing mice. Results Compared with model group, the survival time of the mice in GFB group was significantly longer (P<0.05, 0.01), the survival time of GFB-L-40 group was significantly longer than that of GFB-S-40 group (P<0.05), and body weight growth of model group was the fastest; The order of tumor growth speed was as follows:model group > GFB-S-20 group > GFB-S-40 group > GFB-L-20 group > GFB-L-40 group; GFB significantly improved the number decreasing of autonomic activities of tumor bearing mice, and there was significant difference between the same dose of solution and liposome group (P<0.05). Conclusions GFB liposomes could prolong the survival time and improve the quality of life obviously in S180 bearing mice, which is better than GFB solution.