It has been proved that ursolic and oleanolic acids possess nephroprotective effects against drug(ie aristolochic acid, adriamycin, gentamycin, carbon tetrachloride or cyclosporine)-, hyperglycemia-, hypertension-, obstruction-, ischemia-reperfusion- induced renal injury and grafting kidney by animal experiments. Ursolic and oleanolic acids have the improving actions on natriuresis, glomerular filtration rate and creatinine clearance in normal and kidney-injured animals. Ursolic acid inhibits proliferation against various prostate cancer cells and bladder cancer cells, and induced apoptosis. It has been proved by animal experiments in vivo that ursolic acid inhibits the initiation and progression of prostate cancer in mice, and testosterone-induced benign prostatic hyperplasia in rats. Ursolic acid at lower concentration can reduce the adhesion of uropathogenic Escherichia coli strains to uroepithelial cells, and prevent from urinary tract infections. Oleanolic acid can reduce the urinary calcium output, and prevent from urolithiasis.