目的 评价沙丁胺醇与硫酸镁联合雾化吸入治疗支气管哮喘的临床效果。方法 选取科右前旗人民医院2013年3月到2015年3月门诊确认的100名支气管哮喘的患者为研究对象,按照随机以及结合患者意愿的方法分为观察组与对照组。两组患者在年龄、性别、病情等方面差异无统计学意义。对照组给予沙丁胺醇雾化吸入治疗,观察组给予沙丁胺醇与硫酸镁联合雾化吸入治疗。通过检测患者的肺功能恢复情况,第一秒用力呼气量(FEV1)、最大呼气流量(PEF),评价此种方法的临床效果以及安全性。结果 两组患者在治疗后,FEV1与PEF相对比激发值均有提高(P<0.05);观察组的患者的FEV1与PEF的上升率高于对照组(P<0.05),且恢复后的FEV1与PEF值高于对照组。在20 min后,患者的肺功能值恢复至正常值。在观察组中出现1(2%)例副作用的患者。结论 沙丁胺醇与硫酸镁雾化吸入对于支气管哮喘的治疗有积极的临床治疗效果,但是对于进一步的使用,需要进行更深的研究与探索,减少其对患者的副作用。
Objective To evaluation the clinical efficacy of salbutanmol and magnesium sulfate aerosol inhalation in treatment of bronchial asthma. Methods 100 cases with bronchial asthma in our hospital were chosen, who were randomly divided into the observation group and control group according to patients will. The age, sex, disease of two groups had no significant difference. The control group were given salbutamol aerosol inhalation, he observation group were given salbutamol and magnesium sulfate combined with atomization inhalation treatment. The lung function recovery of FEV1 (force dexpiratory volune), PEF (peak expiratory flow) of patients were detected, the clinical efficacy and safety of the method were evaluated. Results Compared with stimulation value, the FEV1 and PEF after treatment were all improved (P < 0.05), the escalating rate of the observation group FEV1 and PEF were higher than the control group (P < 0.05), the EFV1 and PEF after recovery were higher than the control group. The lung function after treatment for 20 min were back to normal. The observation group had one patient with adverse reaction (2%). Conclusion The salbutamol and magnesium sulfate aerosol inhalation in treatment of bronchial asthma had positive clinical treatment efficacy, while in the further use, which need further research and exploration and reduce the patient's adverse reaction.