目的 探讨不同心衰药物对老年心衰患者的效果,并评价其经济学情况,以期选择合适方法,降低医疗费用支出。方法 选取2012年1月—2015年1月56例老年心衰患者为研究对象,随机分成2组,每组28例。对照组予去乙酰毛花苷注射液治疗,观察组予毒毛花苷K注射液治疗,观察治疗后在药效和经济学指标变化情况。结果 疗效上,对照组与观察组心血管不良事件发生率均为21.42%,两组比较差异无统计学意义;对照组血小板减少、味觉障碍、肝肾功能损害、消化道反应、皮疹发生率分别为17.86%、10.71%、14.29%、17.86%、7.14%;观察组血小板减少、味觉障碍、肝肾功能损害、消化道反应、皮疹发生率分别为14.29%、10.71%、17.86%、14.29%、10.71%,两组差异无统计学意义;两组治疗后血小板、中性粒细胞、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)较治疗前无变化,治疗前后比较差异无统计学意义;对照组每盒单价为52.31元,观察组每盒为12.61元,加上各自的其他治疗费用,对照组平均为(6 415.45±535.56)元/人,观察组为(4 884.25±243.45)元/人,两组比较差异有统计学意义(P<0.05)。结论 毒毛花苷K治疗老年心衰效果与去乙酰毛花苷注射液相当,医疗费用支出较低,更加经济实惠。
Objective To investigate the regimen efficacy of different prescriptions in elderly patients with heart failure, and evaluate the economic situation, in order to choose the right method and decrease the medicine fee. Methods The elderly patients (56 cases) with heart failure from January 2010 to January 2013 were chosen and divided into two groups, the control group had 28 cases, given Deslanoside Injection, the observation group had 28 cases, given Strophanthin K Injection, the effectiveness and economic indicators after treatment were observed. Results The incidence of cardiovascular adverse events in control group was 21.42%, the observation group was 21.42%, without significant difference (P > 0.05). The incidence of thrombocytopenia, taste disorders, liver and kidney function damage, gastrointestinal tract reaction in control group were 17.86%, 10.71%, 14.29%, 17.86%, and 7.14%, while those in the observation group were 14.29%, 10.71%, 17.86%, 14.29%, and 10.71%, without significant difference (P > 0.05). The platelets, neutrophils, PT, and APTT of two groups after treatment had no significant differences (P > 0.05), and the each unit price of control group was 52.31 yuan, the observation group was 12.61%, with their other treatment, the control group average was (6 415.45 ± 535.56) yuan/person, while that in the observation group was (4 884.25 ± 243.45) yuan/person,with statistical significance (P < 0.05). Conclusion Strophanthin K Injection in treatment of heart failure in elder patients had obviously efficacy, the medical expense was low and more economical and practical.