目的 研究联合使用复方甘草酸苷片和生长因子凝胶治疗面部激素依赖性皮炎的临床疗效。方法 选取延安大学咸阳医院收治的面部激素依赖性皮炎患者共148例,随机分为对照组和观察组,每组各74例。其中对照组单独使用复方甘草酸苷片治疗;观察组联合使用复方甘草酸苷片和生长因子凝胶。两组均持续进行4周的治疗,每周测量患者皮损面积,记录患者治疗前后皮损面积和瘙痒程度的变化,并评价最终临床疗效。结果 经过治疗后,观察组和对照组均可以显著降低皮损面积,与治疗前比较差异显著(P<0.05、0.01)。经过治疗后,患者临床症状积分和瘙痒评分均显著降低(P<0.01),且观察组患者皮损面积、临床症状积分、瘙痒评分均显著低于对照组(P<0.05)。经过治疗后,观察组的总有效率显著优于对照组,差异有统计学意义(P<0.05)。结论 联合使用复方甘草酸苷片和生长因子凝胶效果显著,可以在临床推广使用。
Objective To investigate the clinical analysis on Compound Glycyrrhizin Tablets (CGT) combined with Growth Factor Gel (GFG) in treatment of hormone dependent dermatitis. Methods Patients (148 cases) with hormone dependent dermatitis in Xianyang Hospital, were randomly divided into the observation group and control group. The patients of observation group were given CGT combined with GFG, while the control group were given CGT. The treatment were for 4 weeks, the patients with skin lesion area were measured every weeks, the skin lesion clinical observation indexes before and after treatments were recorded, and the final itching grade and final clinical efficacy evaluation results were recorded. Results The observation and control group could obviously decrease skin lesion after treatment (P<0.05, 0.01), the skin lesion area and skin lesion clinical observation indexes were significant lower than those in the control group (P<0.05), the itching grade of observation group was obvious lower than that of the control group (P<0.05), the total efficacy of observation group was higher than that of the control group (P<0.05). Conclusion The efficacy of CGT combined with GFG was significant, which could be worth of promotion, and has certain improved space.