目的 分析甘草锌颗粒联合酪酸梭菌活菌散治疗小儿迁延性腹泻的临床疗效,为小儿迁延性腹泻的治疗提供借鉴。方法 以入渭南市中心医院治疗的迁延性腹泻的患儿128例为研究对象,将患儿随机分为观察组和对照组,每组各64例。两组腹泻时给予去除病因、纠正脱水、电解质及酸碱平衡紊乱,对症支持治疗,在此基础上对照组口服酪酸梭菌活菌散,治疗组在对照组的基础上联合甘草锌颗粒,疗程为10 d,观察大便次数及性状等疗效性。结果 第5天,观察组与对照组患儿迁延性腹泻的总有效率分别为48.44%和31.38%,经秩和检验,差异有显著性(P<0.05)。第10天,总有效率分别为93.75%和92.19%,经秩和检验,差异无显著性。观察组和对照组组内总有效率比较,差异有显著性(P<0.05)。观察组腹痛、腹胀、恶心、呕吐、食欲减退、饮食减少缓解时间与对照组相比,均短于对照组,经比较,差异有显著性(P<0.05)。治疗前两组患儿CD4+、CD8+细胞分数及其细胞比值比较,差异无显著性;治疗后,CD4+、CD8+细胞分数及其比值比较,观察组患儿CD4+及细胞比值明显高于对照组,观察组患儿CD8+及细胞比值明显低于对照组,差异有显著性(P<0.05)。结论 甘草锌颗粒联合酪酸梭菌活菌散治疗迁延性腹泻可改善患儿营养状况并纠正肠道菌群,缩短病程,提高机体免疫力。
Objective To analyze the clinical effects of licorzine granules with clostridium butyricum powder in treatment of protracted diarrhea in infants, in order to provide guidance for treatment of protracted diarrhea in infants. Methods Infants with protracted diarrhea were selected and randomly divided into observation group and control group. The treatment for both groups included removing the causes, correcting dehydration and the electrolyte disorder and symptomatic relief and supportive treatment. Clostridium butyricum powder was given to the infants of control group, and licorizine granules combined with clostridium butyricum powder was given to the infants of observation group. The treatment was lasting for 10 d with the observation indexes such as number and shape of defecation. Results Infants (128 cases) were in this research, with 64 cases in each group. The total effective rates of observation group and control group in day 5 were 48.44% and 31.38%, and the difference was statistically significant (P < 0.05). The total effective rates of observation group and control group in day 10 were 93.75% and 92.19%, and the difference was no statistically significant (P > 0.05). The effective rate in intra-group comparison was statistically significant (P < 0.05). The relief time of stomachache, bloating, nausea, loss of appetite and decrease of diet in observation group was much shorter than that in the control group with statistically significance (P < 0.05). Before treatment, the percentage and ratio of CD4+ cells and CD8+ cells had no statistically significance in both groups (P > 0.05). After treatment, the percentage and ration of CD4+ cells and CD8+ cells in observation group was higher than control group with statistically significance (P < 0.05). Conclusion Zinc agent with clostridium butyricum powder in treatment of protracted diarrhea in infants has good effect, which can improve nutrition outcomes, correct intestinal flora, shorten the length of the disease and enhance the body immunity.