目的 探讨仙灵骨葆胶囊治疗绝经后骨质疏松(PMOP)性Colles骨折的临床疗效。方法 124例绝经后轻创伤性稳定型Colles骨折女患者随机分成治疗组与对照组,每组62例。两组给予相同的闭合手法复位、腕自由位小夹板前臂固定,治疗组po仙灵骨葆胶囊3粒/次,对照组po三七片3片/次,均2次/d,连服12周。于治疗后次日和第4、8、12周抽血检测血清碱性磷酸酶(ALP),治疗第6周拆除夹板拍摄X片观察骨痂生长情况,第12周观察残余肿胀、腕关节活动恢复等情况,比较两组的疗效及不良反应。结果 两组患者血清ALP、骨愈合X线评分和优良率、残余肿胀、腕关节功能恢复等情况比较,治疗组优于对照组,两组差异均有统计学意义(P<0.05)。结论 仙灵骨葆胶囊治疗PMOP性Colles骨折的临床效果显著,可促进骨痂生长,安全性高,不良反应少,能较早进入功能锻炼,获得较为满意的功能恢复,可作为PMOP骨折治疗的理想选择。
Objective To evaluate the clinical effects of Xianling Gubao Capsules (XGC) in treatment of postmenopausal women osteoporotic Colles fracture. Methods Postmenopausal women (124 cases) with mild traumatic stable Colles fractures were randomly divided into control group and treatment group, 62 cases in each group. The two groups were given the same closed manipulative reduction and mall splint forearm fixation (not fixed wrist joint). The patients in control group received oral Sanqi Tablets, the patients in treatment group were orally given XGC, 2 times a day, 3 pills each time, continuously for 12 weeks. On the day after reduction, 4, 8 and 12 weeks were detected the serum alkaline phosphatase (ALP), 6 weeks removed splint, and shoot X-tablets, understanding the growth state of the bone scab. In the 12th week, the degree of residual swelling and wrist joint activity recovery were observed. The treatment effect and untoward reactions of the two groups were compared. Results The serum ALP, bone healing X-ray score, excellent rate of bone healing, residual swelling, and wrist joint function recovery in traetment group were better than ontrol group, the difference was statistically significant (P < 0.05). Conclusion The clinical effect of XGC in the treatment of postmenopausal women with osteoporosis of the trauma type Colles fracture is significant, can promote callus growth and high safety, and adverse drug reactions occurred less. Patients can enter the functional exercise early and get a more satisfactory functional recovery. Therefore, it can be used as an ideal choice for the treatment of osteoporotic fracture in postmenopausal women.