目的 探讨疏肝解郁胶囊联合兰索拉唑和莫沙必利治疗伴有抑郁焦虑状态的功能性消化不良的临床效果。方法 选取2012年12月—2014年6月106例伴抑郁焦虑状态的功能性消化不良患者为研究对象,随机分成2组,对照组53例,予联合兰索拉唑和莫沙必利;观察组53例,在对照组的基础上加用疏肝解郁胶囊治疗,观察治疗后疗效、不良反应等指标变化情况。结果 疗效上,对照组痊愈率为24.53%、总有效率为79.25%,观察组痊愈率为39.62%、总有效率为94.34%,观察组在痊愈率和总有效率上显著优于对照组(P<0.05);两组治疗后在抑郁、焦虑评分上均较治疗前显著下降,治疗前后比较差异显著(P<0.05),治疗后观察组抑郁、焦虑评分显著优于对照组(P<0.05);两组治疗后NOS较治疗前显著下降,5-HT较治疗前显著升高,治疗前后比较差异显著(P<0.05),治疗后观察组5-HT、NOS显著优于对照组(P<0.05);对照组睡眠障碍、头晕、便秘等不良反应发生率为58.49%,观察组睡眠障碍、头晕、便秘等不良反应发生率为20.75%,观察组显著低于对照组,两组比较差异显著(P<0.05)。结论 疏肝解郁胶囊联合兰索拉唑和莫沙必利治疗伴有抑郁焦虑状态的功能性消化不良临床疗效满意。
Objective To investigate the clinical efficacy of Shugan Jieyu Capsule (SJC) in treatment of functional dyspepsia combined with depression and anxiety state, in order to improve the clinical efficacy. Methods Patients (106 cases) with liver resolve depression capsule in treatment of functional dyspepsia combined with depression and anxiety state were chosen as two groups, the control group had 53 cases, who were given Western medicine treatment, the observation group were taken with liver resolve depression capsule on the base of control group. The efficacy, adverse reaction after treatment were observed. Results The cure rate of control group was 24.53%, the total efficacy was 79.25%, while those in the observation group were 39.62% and 94.34%, the observation group was higher than the control group (P < 0.05). Compared with that before treatment, the depression anxiety score of two groups after treatment were obviously decreased (P < 0.05). The depression and anxiety score was greater than that in the control group (P < 0.05), the NOS of two group were significant lower than those before treatment, the 5-HT was obviously higher (P < 0.05), compared with control group, the 5-HT and NOS of observation group were higher than the control group (P < 0.05), the adverse reaction of sleep disturbance, dizziness, constipation of control group was 58.49%, the observation group was 20.75%, the control group was significant lower than the control group (P < 0.05). Conclusion The SJC in treatment of functional dyspepsia combined with depression and anxiety state has great clinical efficacy.