目的 研究如意珍宝片对血管性痴呆(VD)大鼠的保护作用。方法 采用改良双侧颈总动脉永久性结扎法制备大鼠VD模型,以Y迷宫为学习记忆评价指标,并测定VD大鼠脑内多巴胺(DA)、去甲肾上腺素(NE)、5-羟色胺(5-HT)3种单胺类神经递质水平。结果 如意珍宝片能显著的增加Y迷宫的正确次数和提高脑内3种单胺类神经递质水平。结论 如意珍宝片能提高VD大鼠学习记忆能力,升高脑内单胺类神经递质水平,从而改善大脑皮层的兴奋性,激活脑损伤后的学习记忆过程。

Objective To investigate the protective effects of Ruyi Zhenbao Tablet (RZT) on vascular dementia in rats. Methods The permanent bilateral common carotid artery ligation method was used to establish the rat model of vascular dementia (VD). The learning and memory abilities were evaluated by Y maze. Besides, the levels of three monoamine neurotransmitters including dopamine (DA), norepinephrine (NE), and 5-hydroxytryptamine (5-HT) within rat brain were also determined. Results The correct number of Y maze and the brain levels of three monoamine neurotransmitters can be significantly enhanced in the VD models treated by RZT compared to other controls. Conclusion RZT was able to enhance the learning and memory abilities of VD rats and protect the monoamine neurotransmitters, as a result the cerebral cortex excitability of the VD rats was improved and thereafter, the learning and memory procedure was exited in the rats with brain injury.