[关键词]
[摘要]
目的 观察金丝桃苷对实验动物中枢神经系统、呼吸系统、心血管系统的影响。方法 以低、中、高剂量(12.5、60.0、300.0 mg/kg)金丝桃苷ig给予BALB/c小鼠,观察小鼠的一般行为、自主活动、入睡只数、入睡时间和协调运动,考察其对小鼠中枢神经系统的影响;以低、中、高剂量(2、12、65 mg/kg)金丝桃苷对麻醉Beagle犬十二指肠给药,观察给药前后麻醉犬的呼吸频率、呼吸幅度、收缩压(SBP)、舒张压(DBP)、平均血压(MBP)、心率(HR)、Ⅱ导联心电图QT间期、QRS波群时间、PR间期、ST段偏移幅度等相关指标的变化,考察其对Beagle犬呼吸系统及心血管系统的影响。结果 与对照组比较,用药后各组小鼠中枢神经系统,Beagle犬呼吸幅度、呼吸频率、血压、心率、心电图均无明显变化。结论 金丝桃苷对小鼠中枢神经系统、Beagle犬呼吸系统及心血管系统均无明显影响,提示其不良反应小。
[Key word]
[Abstract]
Objective To observe the pharmacological actions of hyperoside on physiological functions of central nerve, respiratory system, and cardiovascular system in mice and dogs. Methods Mice were given medicine orally with different doses (12.5, 60.0, and 300.0 mg/kg) of hyperoside, and general behavior, spontaneous locomotor test, cooperation movement ability, and synergistic effect with pentobarbital-sodium in mice were observed. Beagle's dogs were given hyperoside via duodenum with different doses (2, 12, and 65 mg/kg) in order to evaluate the effects of hyperoside on the frequency and depth of respiration, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR), QT, QRS, PR, and ST of electrocardiogram. Results The differences in values of central nervous system in mice and respiratory range, respiratory rhythm, blood pressure and heart rate in dogs after medication showed no statistically significant difference compared with control group (P>0.05). Conclusion Hyperoside has no obvious influence on nervous system in mice, respiratory system, and cardiovascular system in Beagle's dogs.
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[基金项目]
国家自然科学基金(30572350);国家中医药管理局新药开发专项(DIX005A)