中药药效物质基础研究是中药现代研究的关键问题,而血清药物化学为进一步阐明中药药效物质基础提供了方法支持,已成为近年来研究中药及中药复方药效物质基础发展迅速的方法之一。本文对血清药物化学的概念及研究方法进行了回顾,综述近年来其在单味中药及中药复方物质基础研究中的应用进展以及目前存在的问题,并对血清药物化学应用于中药复方研究的发展方向进行了展望。

Serum pharmacochemistry in recent years has become one of the rapid development methods in research of the pharmacodynamics material basis of Chinese materia medica (CMM) and complex prescription. The concepts and the research models of serum pharmacochemistry were reviewed in this article, the progress on the material basis of traditional Chinese medicine and complex prescription in recent years were summarized, and the future prospects of serum pharmacochemistry applied to CMM were discussed.