[关键词]
[摘要]
目的 探讨不同疗程左氧氟沙星联合四联抗结核药治疗结核性胸膜炎的疗效及不良反应。方法 168例结核性胸膜炎患者随机分为治疗组与对照组,各84例。两组均用标准四联抗结核药治疗,对照组(长疗程)在此基础上静脉滴注左氧氟沙星0.6 g/次,1次/d,共4周;治疗组(短疗程)加用相同剂量的左氧氟沙星1周,比较两组的疗效与不良反应。结果 治疗组与对照组的有效率分别为88.1%、89.3%,两组比较差异无统计学意义;随访期间对照组无1例复发,治疗组有1例复发,两组比较差异无统计学意义;两组胸腔积液消失时间差异无统计学意义。对照组不良反应发生率为15.5%,治疗组的为7.1%,两组比较差异有统计学意义(χ2=2.583,P < 0.05)。结论 虽然短疗程与长疗程左氧氟沙星治疗结核性胸膜炎的效果无显著性差异,但短疗程的不良反应发生率较低,值得临床推广应用。
[Key word]
[Abstract]
Objective To discuss the efficacy on tuberculous pleurisy cured by different courses of treatment of levofloxacin combined with anti-tuberculosis drugs. Methods Patients (168 cases) were randomly divided into long course group and short course group and 84 patients were in each group. The patients in both groups were cured by standard four anti-tuberculosis drugs combination. On this bases, the patients in long course group were treated with levofloxacin for 4 weeks, and the patients in short course group were treated with levofloxacin for 1 week. The efficacy and adverse reaction were compared between two groups. Results The efficiencies in long course and short course groups were 88.1% and 89.3%, respectively. The difference was not statistically significant. There was no patient in short course group relapse, but one patient in long course group relapsed. The difference was not statistically significant. The incidence rates of adverse reaction in long course and short course groups were 15.5% and 7.1%, respectively. The difference was statistically significant(χ2=2.583, P < 0.05). Conclusion Compared to long course group, the efficacy of short course group on tuberculous pleurisy has no significant difference, but the incidence rate of adverse reaction is lower, it is worthy of clinic application.
[中图分类号]
[基金项目]
延安市科学技术研究发展计划项目(2012YDFY-Y302)